IndraLab

Statements

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"Theoretically, TREK-1 can be activated by the arachidonic acid release and intracellular pH decrease induced by ischemia."
19084539
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"We previously demonstrated that the incubation of human pregnant myometrial strips with the TREK1 activator arachidonic acid significantly reduced myometrial strip contractility, whereas incubation with the TREK1 inhibitor L-methionine significantly enhanced myometrial strip contractility, confirming the importance of TREK1 in regulating uterine contractility (15–17)."
36909311
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"TREK-1 inhibitor L-methionine partly reversed uterine relaxation caused by the progesterone, while TREK-1 activator arachidonic acid did not cause significant change in progesterone induced relaxation."
29416642
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"The reversible nature of the AA-induced currents further supports the functionality of TREK channels in ACHS.Furthermore, the mechanosensitivity of TREK channels was evaluated by examining their response to osmotic changes."
39063089
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"TREK-1 is reversibly activated by polyunsaturated fatty acids (PUFA) including AA, but not by saturated fatty acids ( Fink et al., 1998 ; Kim et al., 2001a, b ; Patel et al., 1998 )."
18343483
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"In this study, we report that TREK-1 channel is reversibly activated by polyunsaturated fatty acids (PUFAs), as already shown in different studies, each being focused mainly on one PUFA : AA (C20:4 n-6); LA (C18:2 n-6) and DHA(C22:6 n-3) ."
38956407
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"We demonstrate that C22:6 n-3 and C18:2 n-6 are the most potent activators of TREK-1 with a kinetic close to the direct activator ML402 and a fully reversibility.Since TREK-1 channel is mechanosensitive and activated by arachidonic acid in cells and liposomes it is hypothetized that its gate is either mediated by changes in the membrane curvature induced by PUFAs insertion leading to an increase of the mechanical stress transmitted to the channels as for CPZ or by a direct binding of PUFAs."
38956407
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"Since the known membrane curvature inducer AA had been shown previously to reversibly activate TREK-1, we also tested its effect."
32499717