IndraLab

Statements

OTUD3 activates GRP78 protein. 3 / 3
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"We found that WT OTUD3 , but not C76A mutant , increased GRP78 protein level ( Fig. 6a and Supplementary Fig. 6a ) whereas OTUD3 knockdown remarkably decreased GRP78 protein level ( Fig. 6b and Supplementary Fig. 6b ) ."
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"In consistent with these phenomenon , elevated OTUD3 expression increased GRP78 protein level in the lung tissue of OTUD3 TG mice ( Supplementary Fig. 7c , d ) , whereas OTUD3 knockout decreased GRP78 expression in the mouse lung tissue ( Supplementary Fig. 7e , f ) ."
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"Knockdown of OTUD3 results in a decrease in the level of GRP78 protein , suppression of cell growth and migration , and tumorigenesis in lung cancer ."
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