IndraLab

Statements


ZUP1 inhibits NF-B. 3 / 3
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"Importantly, our data showed the DUB activity is responsible for the ability of Nsp11 to inhibit NF-B activation, revealing a novel mechanism evolved by PRRSV to disarm host innate immune responses."

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"As shown in Fig. 6A , the results showed that mutants with impaired DUB activity were attenuated for the ability to suppress NF-B activation."

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"DUB activity is essential for PRRSV Nsp11 to block NF-B activation."