IndraLab

Statements

BST2 binds CD4 and vpu. 3 / 3
| 3
sparser
"While studies have suggested that the Vpu–BST-2 interaction could occur within post-endoplasmic reticulum membranes ( xref ), we cannot rule out the possibility that Vpu could also interact with CD4 and BST-2 in a successive manner."
31213558
sparser
"However, Vpu also binds the HIV cell surface receptor CD4 and the restriction factor tetherin, promoting their ubiquitination and degradation by bringing them in close proximity to the SCF β-TrCP E3 ligase complex ( xref , xref )."
25605733
sparser
"Additionally, we show direct binding of HIV-1 Vpu to CD4 and the recently described restriction factor CD317 (also termed Bst-2 or tetherin), which inhibits retroviral particle release from infected cells xref ."
20179761