IndraLab

Statements

CD4 binds BST2 and vpu. 3 / 3
| 3
sparser
"However, Vpu also binds the HIV cell surface receptor CD4 and the restriction factor tetherin, promoting their ubiquitination and degradation by bringing them in close proximity to the SCF β-TrCP E3 ligase complex ( xref , xref )."
25605733
sparser
"Additionally, we show direct binding of HIV-1 Vpu to CD4 and the recently described restriction factor CD317 (also termed Bst-2 or tetherin), which inhibits retroviral particle release from infected cells xref ."
20179761
sparser
"While studies have suggested that the Vpu–BST-2 interaction could occur within post-endoplasmic reticulum membranes ( xref ), we cannot rule out the possibility that Vpu could also interact with CD4 and BST-2 in a successive manner."
31213558