IndraLab

Statements

EGFR phosphorylates itself on Y1016. 16 / 16
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"Treatment of pancreatic carcinoma cells with purified EFEMP1 activates autophosphorylation of EGFR at the positions Tyr-992 and Tyr-1068, but not at the position Tyr-1048."
19804359
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"EGFR autophosphorylation of Y992 provides a docking site for PLC γ [ xref , xref ] whose activation is a prerequisite to EGFR-mediated cell migration [ xref , xref ]."
21649524
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"These combined data indicate that in lung epithelial cells, PTPµ selectively restrains EGFR autophosphorylation of Y845, Y992, Y1068, and Y1086."
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"By contrast, proproliferative GIV-FA cells showed attenuated EGFR autophosphorylation at Y992, Y1045, and Y1068 but sustained phosphorylation at Y845 ( xref , B and C; and Supplemental Figure S3B)."
20462955
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"Overexpression of PTP μ in EGF-treated cells decreased EGFR autophosphorylation of both Y992 (58% reduction) ( xref , lane 4 vs 3) and Y1068 (42% reduction) ( xref , lane 4 vs 3)."
21649524
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"IR caused EGFR tyrosine phosphorylation, whereas it did not induce EGFR autophosphorylation at Tyr992, Tyr1045, and Tyr1068 or Src-dependent EGFR phosphorylation at Tyr845."
16414009
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"We evaluated the tandem SH2 domains from wild-type phospholipase C γ1 (PLCγ1) fused to enhanced green fluorescent protein (EGFP), hereafter denoted as tSH2-WT, as a biosensor for studying the dynamics of EGFR autophosphorylation at Tyr 992 ."
31164479
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"These results suggest that autophosphorylation of EGFR at tyrosine 992 is indispensable for EGF-induced membrane ruffle formation."
12586341
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"Promigratory GIV-wt cells displayed enhanced EGFR autophosphorylation at Y992, Y1045, and Y1068, whereas Src-dependent phosphorylation at Y845 was similar to controls ( xref , B and C; and Supplemental Figure S3B)."
20462955
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"We show that in highly motile GIV-wt cells with an intact GEF motif, EGFR autophosphorylation at Y992, Y1045, and Y1068 and the corresponding adaptor recruitment (PLCγ, cCbl, and Grb2) are enhanced, whereas in rapidly proliferating, GEF-deficient GIV-FA cells these events are suppressed."
20462955
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"Importantly, blockade of EGFR kinase activity by pretreatment with erlotinib, as visualized by reduced auto-phosphorylation of nEGFR at Y992, reduced AGO2 phosphorylation at Y393 in response to irradiation ( xref )."
29253018
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"It was revealed that Cu(edtc) 2 enhanced EGFR autophosphorylation (at approximately 135 kDa) at the site of Y992 but not Y1068 at 0.5 h after treatment with Cu(edtc) 2 ( xref A–C)."
30352976
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"These results, taken together, suggest that autophosphorylation of EGFR at tyrosine 992 and the subsequent PLC gamma 1 activation transduce the signal to Rac1 to induce membrane ruffle formation."
12586341
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"Here, we show that autophosphorylation of EGFR at tyrosine 992 is required for EGF-induced membrane ruffle formation in CHO cells."
12586341
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"The results obtained suggest that the autophosphorylation of EGFR at tyrosine 992 is required for EGF-induced membrane ruffle formation and that the docking enzyme PLCγ1 mediates the signaling from th[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12586341
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"In pancreatic adenocarcinomas, Fibulin-3 binds EGFR (competitive to EGF) causing autophosphorylation of EGFR at Tyr-992 and Tyr-1068 and the subsequent phosphorylation of AKT at Thr-308 and ERK at Thr-202 and Tyr-204 and, thus, accelerates pancreatic adenocarcinoma growth xref ."
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