IndraLab

Statements

USP10 binds PTEN. 12 / 12
4 | 7 1
reach
"Therefore, we conclude that USP10 interacts with PTEN and AMPKalpha, inhibits their polyubiquitylation, and as a result stabilizes PTEN and AMPKalpha.Next, we examined whether Rapamycin, a well known [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
30056112
biogrid
No evidence text available
28852924
reach
"Inversely, endogenous PTEN and AMPKalpha interacted with endogenous USP10 in HCC-LM3 and HUH7 cells."
30056112
biogrid
No evidence text available
28852924
biogrid
No evidence text available
24270891
reach
"Mechanistically, USP10 interacts and stabilizes PTEN and AMPKalpha by inhibiting their polyubiquitylation."
30056112
reach
"We further demonstrated that USP10 directly interacted with and stabilized PTEN via deubiquitination."
28852924
reach
"Furthermore, USP10 can also interact with and deubiquitinate PTEN, USP10 inhibition stimulates tumor growth and invasion, but this effect can be abolished by reinserting PTEN (Sun et al., 2018)."
30319415
sparser
"We found using co-immununoprecipitation/immunoblotting that USP10 interacted with PTEN and reduced the K63-linked polyubiquitination of PTEN mediated by TRIM25 in non-small cell lung cancer (NSCLC) cells."
34416231
reach
"Mechanistically, USP10 interacts with and stabilizes PTEN and AMPKalpha by inhibiting their polyubiquitylation, and subsequently suppresses the activity of mTOR signaling pathway."
30056112
biogrid
No evidence text available
24270891
reach
"The interaction between USP10 and Phosphatase And Tensin Homolog (PTEN) was examined by co-immunoprecipitation."
28852924