IndraLab

Statements

KCNMA1 inhibits GAST. 12 / 12
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"SLO secreted by GAS within these compartments does not prevent the fusion of GAS containing vacuoles with lysosomes, as occurs in keratinocytes."
25227466
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"We now report that low-level production of SLO by an inducible expression system reduced GAS internalization by keratinocytes."
21325037
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"LL-37-induced upregulation of SLO and hyaluronic acid capsule significantly reduced internalization of GAS by keratinocytes and phagocytic killing by neutrophils and macrophages."
23093388
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"This discrepancy provides strong evidence that SLO prevents the internalization of GAS through the action of extracellular toxin on the host cell membrane, whereas inhibition of lysosomal colocalization and the acidification of internalized GAS depends on the secretion of SLO by intracellular bacteria."
21325037
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"Because both the hyaluronic acid capsule and SLO inhibit GAS internalization by oropharyngeal keratinocytes, we used isogenic mutants deficient in production of these factors to investigate their contribution to the resistance to internalization induced by LL-37."
23093388
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"We have shown previously that production of SLO and the associated toxin NADase reduces the internalization of GAS by human oropharyngeal keratinocytes and interferes with trafficking of internalized GAS to lysosomes for efficient intracellular killing."
21325037
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"Inducible expression of SLO inhibits GAS internalization by keratinocytes and intracellular trafficking to lysosomes."
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"Taken together, these data indicate that the co-expression of SLO and NADase by GAS inhibits maturation of GAS containing autophagosomes into degradative autolysosomes, and that this delay is associated with prolonged bacterial survival in infected keratinocytes."
23762025
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"Parallel experiments with 188SLO - / NADase - (piSLO) showed a degree of inhibition of internalization upon the induction of SLO expression similar to that observed in 188SLO - (piSLO), a result that implies that SLO is sufficient to inhibit GAS uptake in the absence of NADase."
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"These results supported the hypothesis that SLO prevents GAS entry into keratinocytes and are consistent with earlier findings that the internalization of parent strain 188 was reduced compared to that of isogenic SLO mutant strain 188SLO -."
21325037
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"We conclude that SLO stimulates xenophagy in pharyngeal keratinocytes, but the coordinated action of SLO and NADase prevent maturation of GAS containing autophagosomes, thereby prolonging GAS intracellular survival."
23762025
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"However, Hakansson et al. reported that SLO markedly reduced the efficiency of GAS internalization by human keratinocytes and interfered with the trafficking of internalized GAS to lysosomes for efficient killing."
21325037