IndraLab

Statements

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"Apical maxi-K (KCa1.1) channels mediate K+ secretion by the mouse submandibular exocrine gland."
18216162
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"Mutations in KCNMA1, the human gene encoding the pore forming α subunit of the large-conductance calcium ion (Ca )- and voltage-activated potassium ion (K ) channel BK (maxi K , K 1.1, Slo1) are linked to a growing number of clinically relevant phenotypes."
37989805
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"To minimize the contribution of intermediate (KCa3.1) and Big (KCa1.1) calcium activated potassium currents, we performed electrophysiological recording in presence of the inhibitors TRAM-34 and TEA at the membrane voltage near the equilibrium potential of K ."
31501459
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"The present study characterizes the effects of Abeta31-35, a short active fragment of amyloid beta-peptide (Abeta), upon the BK channel mediated K+ current and intracellular free Ca (2) + concentration ([Ca (2) +] i) of freshly dissociated pyramidal cells from rat CA1 hippocampus by using whole-cell patch-clamp recording and single cell Ca (2) + imaging techniques."
24680749
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"89 When the intracellular calcium concentration increases, the calcium ion binds to the calcium sensor, and then opens the BK channel, which causes potassium ion outflow, leading to membrane hyperpolarization and vasodilation."
33614016
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"These observations suggest that emodepside is a SLO-1 agonist, activating potassium currents to inhibit neuromuscular function."
34293063
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"Functional effects of expression of hslo Ca2+ activated K+ channels in cultured macrovascular endothelial cells."
9502199
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"The BK channel in the renal connecting tubule expresses the β2 subunit and deleting this subunit in mice has resulted in high renal potassium retention and hyperkalemia (Yan et al., 2022)."
38584598
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"Thus, at ribbon synapses in salamander rod photoreceptors, BK channel activity has been shown to increase the extracellular potassium concentration within the synaptic cleft with consequent enhancement of calcium channel currents, and synaptic amplification."
26969302
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"Effects of amyloid beta-peptide fragment 31-35 on the BK channel mediated K+ current and intracellular free Ca (2) + concentration of hippocampal CA1 neurons."
24680749
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"Maurotoxin, a 34-amino acid toxin from Scorpio maurus scorpion venom, was examined for its ability to inhibit cloned human SK (SK1, SK2, and SK3), IK1, and Slo1 calcium activated potassium (K (Ca)) channels."
12527813
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"In the depolarized membrane potential, the opening of the BK channel produces an outflux of potassium ions (K )."
36329866
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"When the membrane potential is hyperpolarized artificially by voltage ramp, the opening of the BK channel induces an influx of potassium ions (K ), which causes inward currents."
36329866
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"Together, these results support the notion that the localization of SLO-1 near L-type Ca 2+ channels where calcium entry gives rise to high local concentrations is essential for proper SLO-1 function, and that the potassium current mediated by SLO-1 attenuates calcium dependent excitation of muscle."
20019812
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"In addition, salicylate was found to enhance the outward potassium currents mediated by the BK channel when exogenously expressed in HEK293 cells."
39397241
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"These results strongly suggest that calcium activated potassium conductance is almost exclusively mediated by KCa3.1 and KCa1.1 in THP-1 macrophages."
28507328
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"New research reveals that the functional big potassium (BK) channel changes caused by the various KCNMA1 alleles may be linked to patient symptoms that are somewhat distinct."
37727158
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"tend towards this view and demonstrated that high aldosterone concentration in low Na +, high K + diet mice contributes to a high rate of BK channel mediated potassium secretion, which leads to an osmotic diuresis."
28955251
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"Adrenaline induced colonic K+ secretion is mediated by KCa1.1 (BK) channels."
20351045
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"proposed that flow stimulated BK channel mediated potassium secretion is related to a signal pathway that involves an increase in Ca 2+ concentration, which enables BK channels to translocate from the cell to the apical membrane."
28955251
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"The role of the BK channel in potassium homeostasis and flow induced renal potassium excretion."
17579662
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"However, BK channel activation will enhance efflux of potassium ions upon increased intracellular Ca 2+."
33329012
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"Several BK channel potentiating compounds exist, have been well-studied, and can be used to increase epithelial potassium efflux."
38820569
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"Mechanistically, the p.D434G BK channel variant displays increased calcium sensitivity and enhanced potassium current [74]."
37374132
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"In this way, SLO-induced K+ efflux was able to activate the NLRP3 inflammasome (144)."
36761775
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"The p.N995S BK channel enhances both channel open probability and duration and hence increases potassium current."
37374132
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"In response to alcohol, the BK channel may directly modulate neuronal firing and excitation by regulating potassium conductance, which ultimately leads to changes in neurotransmitter release and subsequent behavioral changes associated with alcohol that lead to tolerance."
38999947
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"Role of NKCC in BK channel mediated net K+ secretion in the CCD."
21816753
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"Aldosterone increases KCa1.1 (BK) channel mediated colonic K+ secretion."
18617563
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"Apical maxi-K (KCa1.1) channels mediate K+ secretion by the mouse submandicular exocrine gland."
19448731
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"Large conductance (BK) calcium activated potassium channels (Slo) are ubiquitous and implicated in a number of human diseases including hypertension and epilepsy."
22538239