IndraLab

Statements

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"Functional effects of expression of hslo Ca2+ activated K+ channels in cultured macrovascular endothelial cells."
9502199
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"Aldosterone increases KCa1.1 (BK) channel mediated colonic K+ secretion."
18617563
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"89 When the intracellular calcium concentration increases, the calcium ion binds to the calcium sensor, and then opens the BK channel, which causes potassium ion outflow, leading to membrane hyperpolarization and vasodilation."
33614016
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"These observations suggest that emodepside is a SLO-1 agonist, activating potassium currents to inhibit neuromuscular function."
34293063
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"When the membrane potential is hyperpolarized artificially by voltage ramp, the opening of the BK channel induces an influx of potassium ions (K ), which causes inward currents."
36329866
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"Bithionol is, however, not selective for K Na channels in that it also activates Slo1 calcium activated potassium channels."
24319675
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"These results strongly suggest that calcium activated potassium conductance is almost exclusively mediated by KCa3.1 and KCa1.1 in THP-1 macrophages."
28507328
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"The role of the BK channel in potassium homeostasis and flow induced renal potassium excretion."
17579662
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"Pharmacological block of BK channels in WT NMJs did not affect NMJ function, surprisingly suggesting that the reduced vesicle release in BK-/- NMJs was not due to loss of BK channel mediated K+ current."
32243496
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"Reduction in renal blood flow following administration of norepinephrine and phenylephrine in septic rats treated with Kir6.1 ATP sensitive and KCa1.1 calcium activated K+ channel blockers."
26277325
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"Large conductance (BK) calcium activated potassium channels (Slo) are ubiquitous and implicated in a number of human diseases including hypertension and epilepsy."
22538239
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"The present study characterizes the effects of Abeta31-35, a short active fragment of amyloid beta-peptide (Abeta), upon the BK channel mediated K+ current and intracellular free Ca (2) + concentration ([Ca (2) +] i) of freshly dissociated pyramidal cells from rat CA1 hippocampus by using whole-cell patch-clamp recording and single cell Ca (2) + imaging techniques."
24680749
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"In the depolarized membrane potential, the opening of the BK channel produces an outflux of potassium ions (K )."
36329866
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"However, BK channel activation will enhance efflux of potassium ions upon increased intracellular Ca 2+."
33329012
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"Maurotoxin, a 34-amino acid toxin from Scorpio maurus scorpion venom, was examined for its ability to inhibit cloned human SK (SK1, SK2, and SK3), IK1, and Slo1 calcium activated potassium (K (Ca)) channels."
12527813
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"Apical maxi-K (KCa1.1) channels mediate K+ secretion by the mouse submandibular exocrine gland."
18216162
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"Adrenaline induced colonic K+ secretion is mediated by KCa1.1 (BK) channels."
20351045
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"Together, these results support the notion that the localization of SLO-1 near L-type Ca 2+ channels where calcium entry gives rise to high local concentrations is essential for proper SLO-1 function, and that the potassium current mediated by SLO-1 attenuates calcium dependent excitation of muscle."
20019812
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"tend towards this view and demonstrated that high aldosterone concentration in low Na +, high K + diet mice contributes to a high rate of BK channel mediated potassium secretion, which leads to an osmotic diuresis."
28955251
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"To minimize the contribution of intermediate (KCa3.1) and Big (KCa1.1) calcium activated potassium currents, we performed electrophysiological recording in presence of the inhibitors TRAM-34 and TEA at the membrane voltage near the equilibrium potential of K ."
31501459
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"Effects of amyloid beta-peptide fragment 31-35 on the BK channel mediated K+ current and intracellular free Ca (2) + concentration of hippocampal CA1 neurons."
24680749
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"proposed that flow stimulated BK channel mediated potassium secretion is related to a signal pathway that involves an increase in Ca 2+ concentration, which enables BK channels to translocate from the cell to the apical membrane."
28955251
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"Role of NKCC in BK channel mediated net K+ secretion in the CCD."
21816753