IndraLab

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MIR145 decreases the amount of IRS1. 6 / 13
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"Consistently, immunohistochemical analysis showed a reduction of expression of IRS1 and angiogenesis biomarker CD31, which was reversed by the addition of miR-145 antagomir."
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"A previous report shows that miR-145 can down-regulate the protein level of IRS1 but can not down-regulate the mRNA of IRS1 XREF_BIBR."
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"Though this study discovered that miR-145 inhibited adipogenesis by down-regulated IRS1 gene expression, and IRS1 further affected adipogenic markers expression, which may finally inhibited adipogensis of porcine preadipocytes."
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"Therefore, miR-145 decreased IRS-1 levels at the translational level, and attenuated insulin signaling by decreasing insulin dependent phosphorylation of insulin receptor substrate-1; this caused a su[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Similarly, up-regulation of miR-145 in DFAT cells reduced IRS1 protein expression dramatically, which may decrease expression of adipogenic marker genes in the present study."
23197937
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"Further research showed that miR-145 inhibits N-RAS and IRS1 expression to suppress AKT and ERK1/2 activation and VEGF expression in colorectal cancer XREF_BIBR."
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