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"Similarly , the DUB Ovarian Tumor Deubiquitinase With Linear Linkage Specificity ( OTULIN ) which hydrolyses linear ubiquitin chains synthesized on RIP1 by LUBAC in TNF-signaling pathways [ 188 ] , was identified to restrict linear ubiquitination of RIP2 , attenuating signaling downstream of NOD2 [ 185 ] ."