IndraLab

Statements

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"In the present study, there are several novel findings regarding UCH-L1 as a negative regulator of maladaptive cardiac remodeling and dysfunction as follows : (i) UCH-L1 expression is enhanced in cardiac myocytes and fibroblasts during the earlier stage of cardiac adaptive hypertrophy and declined in the process of maladaptive responses to the sustained hemodynamic stress; (ii) UCH-L1 inhibits cardiac fibroblast proliferation via suppressing PDGF and PDGFRbeta signaling; (iii) UCH-L1 preferentially enhances PDGF-BB-induced suppression autophagic clearance of p21 WAF1 and Cip1 proteins in cardiac fibroblasts."
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"UCH-L1 siRNA is able to inhibit the proliferation of lung adenocarcinoma cell lines H157 and induce the apoptosis."
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"These results indicate that UCHL1 also promotes RA-repressed proliferation of NB cells."
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"XREF_FIG A, MTT absorbance at 490 nm of A2780-shUCHL1 and A2780-control differed significantly on the 5 th day, indicating that reduced expression of UCHL1 in A2780 cells increased cell proliferation."
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"Of interest, overexpression of UCH-L1 enhanced the PDGF-BB-induced posttranscriptional upregulation of p21 WAF1 and Cip1 protein in cardiac fibroblasts (XREF_FIG), suggesting that UCH-L1 inhibits cardiac fibroblast proliferation via posttranscriptional enhancing the expression of p21 WAF1 and Cip1 to suppress the transition of G1 to S phase."
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"To explore the mechanisms of how reduced expression of UCHL1 promotes cell proliferation, reduces apoptosis and confers cisplatin resistance, we performed a microarray analysis to identify different genes regulated by UCHL1-knockdown."
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"Interestingly, a study found that UCH-L1 inhibits breast cancer cell proliferation by stabilizing p53 and blocking G0/G1 cell cycle [ xref ]."
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"These results suggest that UCH-L1 facilitates autophagic degradation of p21 WAF1 and Cip1 to suppress proliferation of cardiac fibroblasts in chronically pressure overloaded heart, potentially acting as a novel feedback mechanism in the regulation of maladaptive cardiac remodeling and dysfunction."
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"Functionally, ectopic expression of UCHL1 suppressed the colony formation and cell proliferation of breast tumor cells through inducing G0/G1cell cycle arrest and apoptosis."
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"This may concern with the following experimental data showing that CD45RA mAb (2H4) or CD45RO mAb (UCHL1) inhibits antigen specific T cell proliferation by approx."
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"XREF_BIBR Similarly, this DUB is downregulated in some prostate cancer samples and in LNCaP cell line, and overexpression of UCHL1 suppresses the proliferation and anchorage independent growth of LNCaP cells."
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"More strikingly, UCHL1 overexpression suppressed anchorage independent proliferation in a soft agar assay."
21999842
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"These results provide direct evidence that UCH-L1 suppresses vascular lesion formation via inhibiting proinflammatory cytokine TNFalpha mediated VSMC proliferation."
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"To determine the molecular mechanism by which UCH-L1 suppresses cardiac fibroblast proliferation, we examined the effect of adenoviral overexpression of UCH-L1 on PDGF-BB-induced activation of MAPKs including extracellular signal regulated kinase (ERK), c-Jun N-terminal kinases (JNK) and p38, phosphoinositide 3-kinase (PI3K), and signal transducers and activators of transcription 3 (STAT3), that are linked to cardiac fibroblast growth XREF_BIBR."
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"In contrast, UCHL1 was found to play a role as a tumor suppressor and suppress cell proliferation and induce apoptosis in breast cancer and prostate cancer [XREF_BIBR, XREF_BIBR]."
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"Furthermore, cell cycle analysis revealed up-regulation of S phase both in A2780-shUCHL1 and IGROV1-shUCHL1, indicating that UCHL1 knockdown promoted cell proliferation by progressing cell cycle."
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"UCH-L1 inhibits cell proliferation in lung and neuro-blastoma cell lines; when these cell lines were treated with these inhibitors, enhanced cell proliferation was observed, further supporting the anti-proliferative role of UCLH-1 enzymes [59] ."
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"3.2 Reduced expression of UCHL1 in A2780 and IGROV1 reduced cell apoptosis but increases cell proliferation."
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"In contrast to H838 cells, our study reveals UCH-L1 knockdown causes no difference in morphology, apoptosis or proliferation in H157 cells but does reduce the capacity for cell migration."
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"UCH-L1 inhibits cell proliferation in lung and neuro-blastoma cell lines; when these cell lines were treated with these inhibitors, enhanced cell proliferation was observed, further supporting the anti-proliferative role of UCLH-1 enzymes [ xref ]."
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"Our results uncovered for the first time that UCH-L1 facilitates autophagic degradation of p21 WAF1 and Cip1 to suppress proliferation in cardiac fibroblasts, potentially acting as a novel feedback mechanism in the regulation of maladaptive cardiac remodeling and dysfunction."
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"These data suggest that UCHL1 suppresses cell proliferation of breast cancer."
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"Jin et al. disclosed that the inhibition of UCHL1 promoted cell proliferation by increasing cells in S-phase and that the knockdown of UCHL1 reduced cell apoptosis and contributed to cisplatin resistance [63]."
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"Adenoviral overexpession of UCH-L1 inhibited the PDGF induced cardiac fibroblast proliferation without affecting the activation of mitogen activated protein kinases (MAPKs), Akt, and signal transducers and activators of transcription 3 (STAT3)."
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"UCHL1 promotes RA-repressed proliferation of NB cells."
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"Ectopic expression of UCHL1 significantly suppressed the colony formation and proliferation of breast tumor cells, through inducing G0/G1 cell cycle arrest and apoptosis."
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"UCHL1 knockdown in ovarian cancer cell lines where it was overexpressed caused increased proliferation."
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"Importantly, adenoviral over-expression of UCH-L1 dose-dependently inhibited TNFalpha mediated RASMC proliferation (XREF_FIG)."
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"Ectopic UCHL1 expression inhibited colony formation and proliferation of breast cancer cells."
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"UCH-L1 inhibits cell proliferation in lung and neuro-blastoma cell lines; when these cell lines were treated with these inhibitors, enhanced cell proliferation was observed, further supporting the anti-proliferative role of UCLH-1 enzymes [XREF_BIBR]."
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"We showed that knockdown of UCHL1 in ovarian cancer cells promoted cell proliferation by inducing S phase cell cycle and reduced apoptosis."
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"32 In some cancers, the gene for UCHL1 is methylated, and restoration of UCHL1 expression inhibited proliferation in hepatocellular carcinoma."
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"UCHL1 could either positively or negatively regulate cell proliferation of cancer cells [34]."
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"Silencing of UCH-L1 inhibited proliferation, colony formation of hilar cholangiocarcinoma cells in vitro and suppressed tumor growth of hilar cholangiocarcinoma cells in vivo."
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"Then we reduced UCHL1 expression in ovarian cancer cell line A2780 and IGROV1 and found that inhibition of UCHL1 promoted cell proliferation by increasing cells in S phases of cell cycle."
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"Indeed, exogenous overexpression of UCHL1 in LNCaP cells had a significant impact on in vitro growth capacity and reduced proliferation of these cells compared to corresponding mock transduced control cells."
21999842
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"UCHL1 suppress anchorage- independent growth and cell proliferation via AKT phosphorylation and stabilizing p53 levels."
21999842