IndraLab

Statements

USP16 increases the amount of PLK1. 3 / 3
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"We found that, whereas the kinetochore localization of BubR1 was unchanged in both the control and Usp16 knockdown HeLa cells, knockdown of Usp16 in the cells reduced the amount of Plk1 localized on the kinetochores (XREF_FIG) and the binding between Plk1 and BubR1 (XREF_FIG)."
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"It was found that the WT and 3E, but not 3A, Usp16 could restore the level of kinetochore localized Plk1, which was initially reduced by Usp16 knockdown (XREF_FIG)."
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"Because the kinetochore localization of Plk1 is necessary for kinetochore-microtubule attachment and subsequent chromosome alignment, we speculated that suppression of Usp16, i.e., reducing the amount of Plk1 on the kinetochores, would delay the chromosome alignment and anaphase onset."
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