IndraLab

Statements

TP53 binds TP53 and MDM2. 6 / 6
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"MDM2 cannot bind serine 15-phosphorylated p53, resulting in transcription of p53-dependent promoters."
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"Arva et al ( xref ) showed that cells carrying the SNP309 GG genotype exhibited a compromised TP53 response pathway and formed transcriptionally inactive p53-MDM2 complexes in response to stress."
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"Among the other key binding partners, hdm-2 forms a complex with the tumor suppressor p53, resulting in a rapid proteasome-mediated degradation of the p53 protein."
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"A recent study showed that cells that harbor this genotype had a compromised TP53 response pathway and formed transcriptionally inactive p53-MDM2 complexes in response to stress [ xref ]."
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"These signals involve the tumor suppressor p53 protein, a central regulator of cell responses to DNA damage, and the E3 ubiquitin ligase Mdm2, that forms a feedback regulatory loop with p53."
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"One approach to suppress tumor growth involves targeting MDM2-p53 interaction in tumors with TP53 WT and amplified MDM2 gene by using MDM2 inhibitors in order to restore p53 activity and induce apoptosis and cell cycle arrest xref ."
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