IndraLab

Statements

USP2 activates CLOCK. 6 / 6
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"By its action on the ubiquitination status of PER1, and possibly other clock proteins it interacts with, USP2 appears to exert a broad function, modulating both SCN central clock function (as seen by effects on both period length and response to photic stimuli) as well as peripheral clocks (as exemplified by our observations in embryonic fibroblasts)."
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"Apart from its functions within the clock, USP2 also mediates clock output."
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"Thus, the USP2 deubiquitinating enzyme modulates the two major features of clock function - its intrinsic circadian rhythm and its capacity to respond to external cues."
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"The ability of USP2 to modulate these central functions of the clock suggested that it acts on the molecular clock machinery."
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"USP2 may also mediate the response of the clock to inflammation, as the expression of the gene is increased in response to TNFalpha treatment, and CRY1 protein induction in response to this cytokine is abrogated when Usp2 expression is knocked down."
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"Our group showed that USP2 modulates the response of the clock to light [XREF_BIBR]."
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