IndraLab

Statements

TP53 binds MDM2 and RB1. 16 / 17
1 | 1 15
sparser
"It also argues that the trimeric complex was formed through the direct interaction of the three proteins, p53, MDM2, and RB."
10078201
sparser
"It has been shown recently that RB can also bind MDM2 to form a trimeric complex with p53 and, in doing so, prevents MDM2-mediated p53 degradation and rescues the apoptotic function but not the transc[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
11120478
sparser
"These results show that RB forms a trimeric complex with p53 through its binding to MDM2 in vitro."
10078201
sparser
"Our data show that one key difference between p53 and RUNX3 is that the latter binds to the acidic domain of MDM2, a region that is adjacent to the N-terminal domain of MDM2 that interacts with p53 and pRB ( xref , xref )."
19808967
sparser
"MDM2 is thus able to interact with the two tumor suppressor proteins; the site of interaction is different and the MDM2-RB complex is indeed able to bind p53."
28050229
sparser
"Interestingly, it has also been demonstrated that Mdm2 forms a trimeric pRb-Mdm2-p53 complex, with Mdm2 acting as a linker between these two transcription factors."
25201198
sparser
"These results demonstrated that RB can form a trimeric complex with p53 specifically through its interaction with MDM2 in cells."
10078201
sparser
"Alternatively, both p53 and RB might bind to MDM2 simultaneously, and the resulting trimeric complex could prevent MDM2 from its normal function of regulating the activity of p53 in apoptosis, protein[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
10078201
sparser
"Rb, an Egr-1 target gene, forms a trimeric complex with p53 and MDM2 to prevent MDM2-mediated p53 degradation."
11035041
sparser
"The p53 and pRb pathways intersect with the formation of a trimeric p53-MDM2-Rb complex."
24305655
sparser
"To rule out the possibility that RB can directly interact with p53 as well as MDM2, we used an RB-specific antibody, IF8, to immunoprecipitate RB and looked for the coimmunoprecipitation of p53 in the[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
10078201
sparser
"GST-RB was phosphorylated by cyclinE/CDK2 and cyclinD/CDK4, and its ability to interact with MDM2 and to form the p53–MDM2–RB trimeric complex was compared with unphosphorylated GST-RB."
10078201
reach
"P53 is able to repress the expression of several anti-apoptitic genes and, interestingly, the RB-p53-MDM2 complex retains p53-mediated repression function but is unable to induce expression of p53-res[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
15279792
sparser
"Increased formation of the RB, p53, and MDM2 trimeric complex in DNA-damaged cells suggests a role in regulating p53-mediated apoptosis in response to DNA damage; there is known to be a discordance be[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
10078201
sparser
"To test the hypotheses, we initially used in vitro translated p53, MDM2, and RB to investigate the protein–protein interaction between p53 and MDM2 with increasing concentrations of RB."
10078201
sparser
"Besides, it can connect p53 and pRb to form an Rb-Mdm2-p53 trimeric complex for the regulation of p53-induced apoptosis ( xref )."
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