IndraLab

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TP53 binds MDM2 and RB1. 17 / 17
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"These results show that RB forms a trimeric complex with p53 through its binding to MDM2 in vitro."
10078201
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"Increased formation of the RB, p53, and MDM2 trimeric complex in DNA-damaged cells suggests a role in regulating p53-mediated apoptosis in response to DNA damage; there is known to be a discordance be[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
10078201
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No evidence text available
10078201
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"Our data show that one key difference between p53 and RUNX3 is that the latter binds to the acidic domain of MDM2, a region that is adjacent to the N-terminal domain of MDM2 that interacts with p53 and pRB ( xref , xref )."
19808967
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"To rule out the possibility that RB can directly interact with p53 as well as MDM2, we used an RB-specific antibody, IF8, to immunoprecipitate RB and looked for the coimmunoprecipitation of p53 in the[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
10078201
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"Besides, it can connect p53 and pRb to form an Rb-Mdm2-p53 trimeric complex for the regulation of p53-induced apoptosis ( xref )."
33643919
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"Rb, an Egr-1 target gene, forms a trimeric complex with p53 and MDM2 to prevent MDM2-mediated p53 degradation."
11035041
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"GST-RB was phosphorylated by cyclinE/CDK2 and cyclinD/CDK4, and its ability to interact with MDM2 and to form the p53–MDM2–RB trimeric complex was compared with unphosphorylated GST-RB."
10078201
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"The RB-MDM2 interaction does not prevent MDM2 from inhibiting p53-dependent transcription, but the RB-MDM2 complex still binds to p53."
10078201
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"The p53 and pRb pathways intersect with the formation of a trimeric p53-MDM2-Rb complex."
24305655
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"Interestingly, it has also been demonstrated that Mdm2 forms a trimeric pRb-Mdm2-p53 complex, with Mdm2 acting as a linker between these two transcription factors."
25201198
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"It has been shown recently that RB can also bind MDM2 to form a trimeric complex with p53 and, in doing so, prevents MDM2-mediated p53 degradation and rescues the apoptotic function but not the transc[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
11120478
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"MDM2 is thus able to interact with the two tumor suppressor proteins; the site of interaction is different and the MDM2-RB complex is indeed able to bind p53."
28050229
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"To test the hypotheses, we initially used in vitro translated p53, MDM2, and RB to investigate the protein–protein interaction between p53 and MDM2 with increasing concentrations of RB."
10078201
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"These results demonstrated that RB can form a trimeric complex with p53 specifically through its interaction with MDM2 in cells."
10078201
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"It also argues that the trimeric complex was formed through the direct interaction of the three proteins, p53, MDM2, and RB."
10078201
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"Alternatively, both p53 and RB might bind to MDM2 simultaneously, and the resulting trimeric complex could prevent MDM2 from its normal function of regulating the activity of p53 in apoptosis, protein[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
10078201