IndraLab

Statements


SPATA2 binds CYLD, Trim14, and USP. 3 / 3
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sparser
"Instead, SPATA2-PUB binds the USP domain of CYLD, which dimerizes via its B-box and does not contain a PIM sequence [ xref ]."

sparser
"Instead, the SPATA2 PUB domain binds strongly ( K D  10 nM) to the CYLD USP domain and the interaction is strengthened through dimerisation of CYLD, mediated via its B-box domain [ xref ]."

sparser
"SPATA2 binds the USP domain of CYLD via its PUB domain, but in a PIM-independent manner."