IndraLab

Statements

USP9X activates Cell Survival. 30 / 31
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"USP9X has, however, also been proposed to promote tumor cell survival by limiting the degradation of the anti-apoptotic protein Mcl-1."
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"Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival."
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"Activating the mitotic phosphorylation of USP9X promotes cell survival through counteracting mitotic ubiquitination and the ensuing proteasomal degradation of Wilms' tumor protein 1, the latter of which modulates the transcription and secretion of CXC motif chemokine ligand 8/interleukin-8 in mitosis (72)."
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"Importantly, increasing USP24 compensates for the decreased cell survival caused by USP9X deficiency."
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"Usp9x expression increases cell survival and 3D growth, and induces invasion in human PDAC cell line PANC1."
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"From these results we conclude that USP9X and ZBTB38 both contribute to cell survival upon oxidative stress, and that they act in the same pathway."
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"USP9X also stabilizes RNA m6A demethylase ALKBH5 by removing the K48-linked polyubiquitin chain at K57 and promotes AML cell survival (44)."
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"The deubiquitinase USP9X promotes tumor cell survival and confers chemoresistance through YAP1 stabilization."
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"USP9X can deubiquitinate and stabilize MCL1 , a protein essential for the survival of stem and progenitor cells from multiple lineages , thereby promoting cell survival ."
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"Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival."
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"While the E3 ligase complexes SCF beta-TRCP and SCF FBXW7 have been shown to ubiquitinate YAP leading to its degradation XREF_BIBR, XREF_BIBR, XREF_BIBR, USP9X, the only reported YAP DUB, was recently shown to promote tumor cell survival and chemoresistance through deubiquitination and stabilization of YAP 50."
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"Here, we show that deubiquitinase USP9X stabilizes ALKBH5 and promotes AML cell survival."
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"However, in established human pancreatic tumor cells, Usp9x supports tumor cell survival and the malignant phenotype, illustrating wide distinctions in function in murine tumor cell models and bona fide human pancreatic cancer while also highlighting the potential for Usp9x inhibitors to be used in the treatment of human PDAC."
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"USP9X Modulates Cell Survival in Response to High-LET IR."
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"Indeed, USP9X/USP24 promotes cell survival by removing K48-linked polyubiquitin chains from Mcl1, which normally mark the protein for proteasomal degradation [38,39] ."
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"On the contrary, USP9X acts as an oncogene and stabilizes MCL1, a critical antiapoptotic member of the BCL-2 family, and thereby promotes cell survival of multiple myeloma XREF_BIBR."
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"Deubiquitinase USP9X stabilizes RNA m6A demethylase ALKBH5 and promotes acute myeloid leukemia cell survival."
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"USP9X Modulates Cell Survival in Response to High-LET IR Following siRNA screening , we aimed to validate that depletion of USP9X caused a decrease in cell survival following high-LET radiation , but had no impact in response to low-LET protons , in both HeLa cells and also cells derived from head and neck squamous cell carcinoma ."
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"One report has presented evidence that USP9x can promote tumor cell survival through stabilization of the pro survival BCL2 family member MCL1 in human follicular lymphomas and diffuse large B-cell lymphoma and multiple myleomas [XREF_BIBR]."
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"Usp9X inhibition causes massive reduction in MPNST cell viability."
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"Consistent with the results obtained with pharmacological inhibition of Usp9X activity, ST88-14 cells were most strongly affected by Usp9X silencing, with a significant reduction in cell viability observed after just 24 h treatment (Fig. 1d)."
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"The results of LDH release detection indicated that lncRNA FAF overexpression enhanced cell viability in the hypoxia/ischaemia injured cardiomyocytes (Figure 2F)."
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"In contrast, deubiquitinase USP9X, which is overexpressed in some malignancies, stabilizes Mcl-1 and promotes tumor cell survival."
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"Furthermore, USP9X knockdown increased the inhibition of cell viability after cisplatin administration."
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"Here we show that the deubiquitinase USP9X stabilizes MCL1 and thereby promotes cell survival."
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"Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival."
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"The hypothesis that UBP43 is an anti-neoplastic target is consistent with recent work reported with the deubiquitinase USP9X, which promoted cancer cell survival by regulating stability of a pro survival BCL2 family member."
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"Previous studies have suggested that deubiquitinase USP9X stabilizes myeloid cell leukemia sequence 1 (MCL1) and promotes tumor cell survival and apoptosis resistance [XREF_BIBR, XREF_BIBR]."
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"USP9X is involved in fundamental processes such as pre-implantation development and is considered to particularly enhance cell survival by stabilizing different pro survival substrates such as beta-catenin and the pro survival BCL2 family member MCL1 (Taya etal, 1999; Murray etal, 2004; Sacco etal, 2010; Schwickart etal, 2010; Vucic etal, 2011)."
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"Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival."
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