IndraLab

Statements

BAP1 activates PAFAH1B1. 2 / 2
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"Asxl1 deletion and forced expression of Asxl1 mutations induced global reduction of H3K27me3, upregulation of Hox genes,26, 27, 59 and promote development of MDS and AML in combination with Tet mutations,59 Nras mutations,26, 27 and SETBP1 mutations.62 Bap1 is an Asxl1 binding partner, and Bap1 deletion in adult mice also caused MDS like diseases.63 These findings indicate the important role of Asxl1 and Bap1 complex to suppress myeloid transformation."
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"These results suggested that increased BAP1 expression can lead to an MDS-like phenotype in human HSPCs, similar to ASXL1 Y591X overexpression.ASXL1 forms a PR-DUB complex with BAP1, deubiquitinating [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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