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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

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INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

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CHEK2 phosphorylates TP53 on T387. 3 / 3

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"ATM dependent dephosphorylation of p53 at S376 and Chk1 and Chk2 dependent phosphorylation of p53 at S378, S366 and T387 generate 14-3-3 binding sites in vivo."

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"The Chk1 and Chk2 kinases phosphorylate p53 at S366, S378 and T387."

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"Chk1 and Chk2 can also phosphorylate additional p53 residues including T387 by Chk1, T18 and S366 by Chk2, and 4 residues (S313, S314, T377, S378) in the C-terminus by both kinases [XREF_BIBR]."

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INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...

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CHEK2 phosphorylates TP53 on T387. 3 / 3

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