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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

TNFAIP3 decreases the amount of Proteasome. 1 / 1

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"For instance, while it is known that NF-kappaB activates the expression of deubiquitinating enzymes CYLD and A20 (TNFAIP3) that negatively regulate NF-kappaB signaling [XREF_BIBR - XREF_BIBR] as well as expression of the proteasome subunit LMP2 (PSMB9) and proteasome activators PA28-alpha and PA28-beta [XREF_BIBR - XREF_BIBR], OHMM identified the E2 ubiquitin conjugating enzymes UBE2H, UBE2D3 and UBE2M that promote protein ubiquitination, as putative NF-kappaB targets."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...