IndraLab
Statements
TNFAIP3 decreases the amount of Proteasome. 1 / 1
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"For instance, while it is known that NF-kappaB activates the expression of deubiquitinating enzymes CYLD and A20 (TNFAIP3) that negatively regulate NF-kappaB signaling [XREF_BIBR - XREF_BIBR] as well as expression of the proteasome subunit LMP2 (PSMB9) and proteasome activators PA28-alpha and PA28-beta [XREF_BIBR - XREF_BIBR], OHMM identified the E2 ubiquitin conjugating enzymes UBE2H, UBE2D3 and UBE2M that promote protein ubiquitination, as putative NF-kappaB targets."