IndraLab

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USP22 inhibits cell cycle. 15 / 15
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"Importantly, overexpression of MDMX reversed USP22 silencing, induced p53 activation, growth inhibition, cell cycle arrest and apoptosis in A549 cells (XREF_FIG B-E)."
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"As shown, doxycycline (Dox) decreased USP22, resulting in marked loss of AR (XREF_FIG, top), attenuated cell cycle progression (determined by BrdU incorporation XREF_FIG, top right, middle), and significantly suppressed of cell doubling (XREF_FIG, bottom)."
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"Also, USP22 silencing promotes apoptosis and cell cycle arrest in human brain gliomas."
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"RNA interference mediated USP22 gene silencing promotes human brain glioma apoptosis and induces cell cycle arrest."
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"XREF_BIBR - XREF_BIBR Zhang and colleagues have demonstrated that ectopic overexpression of USP22 promotes cell proliferation and that suppression of USP22 expression by small hairpin RNA induces cell cycle arrest in human lung cancer cells."
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"Functionally, this overexpression of USP22 actively contributes to tumorigenesis, as USP22 depletion blocks cancer cell cycle progression in vitro, and inhibits tumor progression in animal models of lung, breast, bladder, ovarian, and liver cancer, among others."
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"USP22 Silencing Inhibits Proliferation and Induces Apoptosis and Cell Cycle Arrest in NSCLC Cells."
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"Meanwhile, our flow cytometry analysis revealed that, compared with the control, USP22 shRNA transfected cells displayed a significantly higher portion of cells at the G0/G1 phases and significantly lower portions of cells at the S and G2/M phases (XREF_FIG C), indicating that USP22 silencing induces cell cycle arrest."
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"Silencing USP22 by asymmetric structure of interfering RNA inhibits proliferation and induces cell cycle arrest in bladder cancer cells."
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"Our group first ensured that knockdown of USP22 can induce cell cycle arrest and inhibit cell growth in the HCC cell line HepG2 (Ling etal., 2012a)."
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"Our in vitro and in vivo studies showed that USP22 silencing by shRNA inhibits proliferation and induces cell cycle arrest and apoptosis in human NSCLC cells in vitro and curbs human NSCLC tumor growth in a mouse xenograft model in vivo."
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"Knockdown of USP22 was found to suppress cell proliferation in vitro and tumour growth in vivo by inducing G1 phase cell cycle arrest through synergy with TGF-beta1 (Ji et al., 2015)."
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"However, Ling et al reported that knockdown of USP22 by siRNA induced cells G0/G1 cell cycle arrest via the c-Myc and cyclin D2 pathway in HepG2 cells."
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"The USP22 silencing both in CNE-1 and CNE-2 cells caused them to accumulate in the G0/G1 phase of the cell cycle."
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"On the other hand, USP22 suppresses the pro apoptotic and cell cycle arrest activity of p53 through SIRT1 [XREF_BIBR]."
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