IndraLab

Statements

Gate activates KCNMA1. 3 / 3
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"For instance, while we can reason that G375R (Liang et al., 2019; Figure 3A) may disrupt the opening of the activation gate since this is part of the diglycine hinge for the BK channel activation gate (Magidovich and Yifrach, 2004) and G356R may destroy the selectivity filter (Tao and MacKinnon, 2019; Figure 3A), we have no clue how the mutations in the cytosolic domain, such as N1053S (Zhang et al., 2015), N536H (Zhang et al., 2020), C413Y, or I663V (Liang et al., 2019; Figure 3A) may affect voltage dependent activation or the intrinsic gate opening in BK channels."
34744799
reach
"Since G375R [32] is located in the diglycine hinge for the BK channel activation gate [63], it is possible that this mutation interacts with the opening of the activation gate and that G356R [32] eliminates the selectivity filter [64]."
36503451
reach
"The BK channel activation gate can open in the absence of voltage sensor activation and Ca 2+ binding with an intrinsic open probability of ~ 10 -7."
25705194