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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

KCNA5 binds PSMD4. 2 / 2

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"Important issues regarding the safety of I Kur blockers have been raised recently with the finding that loss-of-function mutations in KCNA5 are associated with familial AF. xref Because KCNA5 encodes the α subunit of the I Kur channel, these results suggest that a reduction in I Kur may predispose to the development of AF."

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"Indeed, a loss-of-function mutation in KCNA5 associated with AF results in decreased ultrarapid delayed rectifier potassium current ( I Kur ), prolongation of the atrial action potential, and facilitates early afterdepolarizations. xref Recent discoveries have also revealed mechanisms by which mutations in sodium channels may influence AF susceptibility."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...