IndraLab

Statements

USP17L2 inhibits cell population proliferation. 10 / 10
| 10
reach
"Dub-3, which is known as Usp17, is responsible for the regulation of cell growth and survival, and the constitutive expression of Dub-3 can block cell proliferation XREF_BIBR - XREF_BIBR."
22984479
reach
"DUB3 inhibited HCC cell proliferation in vitro and tumor growth in vivo while enhancing the chemosensitivity of HCC cells in a KLF4-dependent manner."
35383144
reach
"More recently, we have also reported that constitutive expression of DUB-3 can block cell proliferation [XREF_BIBR, XREF_BIBR] and subsequently we have demonstrated that this is due to its regulation of the ubiquitination and activity of the ' CAAX ' box protease Ras converting enzyme 1 (RCE1) [XREF_BIBR]."
20403174
reach
"The constitutive expression of DUB-3 can block cell proliferation and initiate apoptosis [25]."
23773437
reach
"Knockdown of Dub3 could inhibit the proliferation of ovarian cancer cells and increase cell apoptosis."
25776484
reach
"DUB-3, a cytokine inducible deubiquitinating enzyme that blocks proliferation."
14699124
reach
"We originally showed that constitutive expression of DUB-3 can block cell proliferation and more recently we have demonstrated that this is due to its regulation of the ubiquitination and activity of the ' CAAX ' box protease RCE1."
20403174
reach
"In particular, DUB-1 expression results in cell cycle arrest prior to S-phase [XREF_BIBR], DUB-2 expression markedly inhibits apoptosis induced by cytokine withdrawal [XREF_BIBR] and we have previously reported that constitutive expression of DUB-3 blocks cell proliferation [XREF_BIBR, XREF_BIBR, XREF_BIBR] through its regulation of the ubiquitination and activity of the ' CAAX ' box protease RCE1 [XREF_BIBR, XREF_BIBR]."
20403174
reach
"Finally, we have demonstrated that constitutive expression of DUB-3 blocks proliferation and can initiate apoptosis in both IL-3-dependent Ba/F3 cells and NIH3T3 fibroblasts."
14699124
reach
"USP17 subfamily members have been previously identified [XREF_BIBR] and one of them, DUB-3, has shown that the constitutive expression of DUB-3 blocks proliferation and can lead to apoptosis [XREF_BIBR]."
17109758