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USP14 increases the amount of PRNP. 2 / 2
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"However, similar to what we observed in the hippocampi (Figure 2), this genetic reduction of USP14 was not sufficient to decrease the levels of the TARDBP, PRNP, or MAPT proteins, as the steady-state levels of these proteins were similar in the cortical neurons cultured from the USP14-deficient mice and the wild type controls (Figure S3)."
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"Treatment with IU1 was reported to reduce the levels of PrP in prion-infected neuronal cells, whereas overexpression of USP14 elevated the levels of PrP in prion-infected cells (Homma et al., 2015)."
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