IndraLab

Statements

USP14 activates AR. 6 / 9
| 6
reach
"However, IU1 did not significantly affect cell growth in the present study, which suggested that USP14 is not critical in ovarian cancer and implied the lack of USP14-mediated androgen receptor signaling in ovarian cancer progression [22, 23]."
31666925
reach
"Nevertheless, loss of USP14 reduced the volume of nuclear AR under DHT stimulation, which may result from the reduction of cellular AR after USP14 silencing."
29353883
reach
"Collectively, the results show that USP14 regulates the total AR level but not AR translocation, and mediates the responsiveness of AR + / ER - breast cancer to androgen."
29353883
reach
"Our gene expression analyses of androgen responsive prostate cancer cells exposed to IU1 or USP14 siRNA show a downregulation of PSA but not AR mRNA expression, suggesting that USP14 might not enhance the transcriptional activity of AR."
28151478
reach
"Thus we present a hypothesis that USP14 increases AR by inhibiting AR degradation, not by promoting AR transcription."
28151478
reach
"In addition, western blot analysis and immunofluorescent staining assay indicated that USP14 silencing significantly downregulated the abundance of AR in both the nucleus and cytoplasm under androgen stimulation, suggesting that cytosolic USP14 is not required for AR translocation and that USP14 silencing induced decrease of nuclear AR could be due to the decrease of total AR protein."
29353883