IndraLab

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TNFAIP3 activates HSPB3. 11 / 11
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"A20, a protein encoded by the tumor necrosis factor alpha induced protein 3 gene (TNFAIP3), plays a vital role in the negative regulation of inflammation and immunity."
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"The variant proximal to NFkappaB1 controls signaling responses by altering the expression of NFkappaB itself, with the GG risk genotype expressing 20-fold more p50 NFkappaB and diminished expression of the negative regulators of the NFkappaB pathway : TNFalpha induced protein 3 (TNFAIP3), B cell leukemia 3 (BCL3), and cellular inhibitor of apoptosis 1 (CIAP1)."
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"Two groups identified a strong association between systemic lupus erythematosus (SLE) and haplotypes that contain variants in the protein coding region of the gene tumour necrosis factor alpha induced protein 3 (TNFAIP3) XREF_BIBR, XREF_BIBR."
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"At least 36 different loci have been identified as susceptibility loci of psoriasis by GWAS [XREF_BIBR], including the TNIP1 gene, which encodes TNF-alpha-induced protein 3 interacting protein 1 (TNIP1), as well as the tumor necrosis factor alpha induced protein 3 (TNFAIP3) gene, which encodes protein A20 [XREF_BIBR, XREF_BIBR]."
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"When younger brother also developed recurrent oral ulcers, genetic studies were performed in the index patent and targeted panel revealed a novel variant in Tumor necrosis factor alpha induced protein 3 (TNFAIP3) gene (XREF_TABLE)."
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"A20 (TNFAIP3, tumor necrosis factor, alpha induced protein 3) is an endogenous negative regulator of the NF-kappaB pathway and is rapidly and transiently induced in response to bacterial and viral sti[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"For example, the TNFAIP3 gene, encoding the tumor necrosis factor α induced protein 3, is up-regulated at both time points (∼3 logFC at 1 h and ∼7 logFC at 4 h) and has two associated induced distal DRs at 1 h and one induced distal DR at 4 h."
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"Other potential hubs includes TRAF6 (TNF receptor associated factor 6), PIN1 (Peptidyl-prolyl cis-trans isomerase NIMA interacting 1), FOS (FBJ murine osteosarcoma viral oncogene homolog), CTNNB1 (Catenin (cadherin associated protein) beta 1), CDKN1A (Cyclin dependent kinase inhibitor 1A (P21, Cip1)-A), TNFAIP3 (Tumor necrosis factor, alpha induced protein 3), SIRT1 (Sirtuin 1), ESR1 (Estrogen receptor 1) and HDAC5 (Histone deacetylase 5)."
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"TNFAIP3 codes for tumor necrosis factor alpha induced protein-3 and has been identified as a risk factor in SSc [XREF_BIBR, XREF_BIBR] particularly with dcSSc, ILD (fibrosing alveolitis) and PAH as well as in individuals with SSc and other autoimmune diseases [XREF_BIBR]."
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"A20 is a cytoplasmic zinc finger protein encoded by the gene TNF-alpha induced protein 3 TNFAIP3."
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"A GWA study reported a new association of the tumor necrosis factor alpha induced protein 3 (TNFAIP3) gene with SLE XREF_BIBR."
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