IndraLab

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TNFAIP3 activates HSPB3. 15 / 15
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"TNFAIP3 codes for tumor necrosis factor alpha induced protein-3 and has been identified as a risk factor in SSc [XREF_BIBR, XREF_BIBR] particularly with dcSSc, ILD (fibrosing alveolitis) and PAH as well as in individuals with SSc and other autoimmune diseases [XREF_BIBR]."
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"A20 (TNFAIP3, tumor necrosis factor, alpha induced protein 3) is an endogenous negative regulator of the NF-kappaB pathway and is rapidly and transiently induced in response to bacterial and viral sti[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Other potential hubs includes TRAF6 (TNF receptor associated factor 6), PIN1 (Peptidyl-prolyl cis-trans isomerase NIMA interacting 1), FOS (FBJ murine osteosarcoma viral oncogene homolog), CTNNB1 (Catenin (cadherin associated protein) beta 1), CDKN1A (Cyclin dependent kinase inhibitor 1A (P21, Cip1)-A), TNFAIP3 (Tumor necrosis factor, alpha induced protein 3), SIRT1 (Sirtuin 1), ESR1 (Estrogen receptor 1) and HDAC5 (Histone deacetylase 5)."
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"A20, a protein encoded by the tumor necrosis factor alpha induced protein 3 gene (TNFAIP3), plays a vital role in the negative regulation of inflammation and immunity."
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"At least 36 different loci have been identified as susceptibility loci of psoriasis by GWAS [XREF_BIBR], including the TNIP1 gene, which encodes TNF-alpha-induced protein 3 interacting protein 1 (TNIP1), as well as the tumor necrosis factor alpha induced protein 3 (TNFAIP3) gene, which encodes protein A20 [XREF_BIBR, XREF_BIBR]."
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"14 , 18 Therefore, further exploration of novel biomarkers to improve risk stratification for T‐ALL patients is needed.Tumor necrosis factor‐alpha‐inducing protein 3 (TNFAIP3), also known as A20, is an inducible protein detected in TNF‐α‐induced endothelial cells."
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"Even though gene burden of TNFAIP3 was still nominally significant, it was much lower compared to the total FTD cohort, indicating that even in the largest clinical subtype the power was limited.The T[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"A20 is a cytoplasmic zinc finger protein encoded by the gene TNF-alpha induced protein 3 TNFAIP3."
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"In addition, the expression of Tnfaip3, which encodes the inflammatory cytokine tumor necrosis factor alpha-induced protein 3, was compared between all of the groups (LG, HG, CPA, TPA, and EPA)."
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"A crucial regulator of NF-κB activation is the anti-inflammatory protein A20 (also known as TNFAIP3 [tumor necrosis factor alpha induced protein 3]), which also has strong anti-apoptotic activities in[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"For example, the TNFAIP3 gene, encoding the tumor necrosis factor α induced protein 3, is up-regulated at both time points (∼3 logFC at 1 h and ∼7 logFC at 4 h) and has two associated induced distal DRs at 1 h and one induced distal DR at 4 h."
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"Tumor necrosis factor alpha-induced protein 3 (TNFAIP3) negatively operates in a feedback loop to prevent NF-kB from being activated."
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"Two groups identified a strong association between systemic lupus erythematosus (SLE) and haplotypes that contain variants in the protein coding region of the gene tumour necrosis factor alpha induced protein 3 (TNFAIP3) XREF_BIBR, XREF_BIBR."
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"A GWA study reported a new association of the tumor necrosis factor alpha induced protein 3 (TNFAIP3) gene with SLE XREF_BIBR."
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"When younger brother also developed recurrent oral ulcers, genetic studies were performed in the index patent and targeted panel revealed a novel variant in Tumor necrosis factor alpha induced protein 3 (TNFAIP3) gene (XREF_TABLE)."
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