IndraLab

Statements

SCN9A binds NAV1. 4 / 4
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sparser
"In addition, our results also showed that only the mouse forms of NaV1.6, NaV1.7 and NaV1.9 sodium channels were expressed in ND7/23 cells that was originally generated as a hybridoma of rat embryonic DRG and mouse neuroblastoma cell-line."
31419255
sparser
"Sodium channel Nav1.7 has emerged as a target of considerable interest in pain research, since loss-of-function mutations in SCN9A , the gene that encodes Nav1.7, are associated with a syndrome of congenital insensitivity to pain, gain-of-function mutations are linked to the debiliting chronic pain conditions erythromelalgia and paroxysmal extreme pain disorder, and upregulated expression of Nav1.7 accompanies pain in diabetes and inflammation."
23134641
sparser
"In particular, Nav1.7 has recently emerged as a target of considerable interest, since loss-of-function mutations in SCN9A , the gene that encodes Nav1.7, are associated with congenital insensitivity to pain [ xref - xref ] and gain-of-function mutations have been linked to pain in erythromelalgia [ xref - xref ] and paroxysmal extreme pain disorder (PEPD) [ xref - xref ]."
23134641
sparser
"Several voltage-gated sodium (NaV) and calcium (CaV) channels are implicated in the etiology of chronic pain, particularly NaV1.1, NaV1.3, NaV1.7-NaV1.9, CaV2.2 and CaV3.2."
32826759