IndraLab

Statements

Modified AKT increases the amount of HIF1A. 3 / 3
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"Similarly, expression of AKT dominant negative mutant also inhibited angiogenesis and tumor growth, and decreased the expression of HIF-1alpha and VEGF in the tumor xenographs."
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"We found that over-expression of AKT by infecting ovarian cancer cells using adenovirus carrying AKT did restore HIF-1alpha expression inhibited by acacetin (XREF_FIG)."
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"Western blot analysis and reverse transcription-polymerase chain reaction in cell experiments revealed that the over-expression of constitutively active AKT (CA-AKT) promotes the expressions of HIF-1alpha protein and VEGF messenger ribonucleic acid in Seoul national university (SNU) -216 and SNU-668 gastric cancer cells under normoxic conditions, whereas kinase dead mutant of AKT down-regulated these expressions under the same conditions."
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