IndraLab

Statements

USP10 binds CFTR. 19 / 21
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"Here, we extend our previous study, conducted using a stably transformed airway epithelial cell line, by demonstrating that USP10 associates with CFTR in primary cultures of polarized human bronchial epithelial cells."
20215869
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"Moreover, USP10 interacted with CFTR in the early endosomes, an important requirement for a DUB to regulate a target protein."
20215869
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"XREF_BIBR, XREF_BIBR Thus, if USP10 regulates the deubiquitination of CFTR, we would predict that USP10 should interact with CFTR in the early endosomal compartment of HBE cells."
20215869
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"The ability of USP10 to deubiquitinate target proteins requires interaction between USP10 and its substrate. xref , xref Thus, if USP10 regulates the deubiquitination of CFTR, we would predict that USP10 should interact with CFTR in the early endosomal compartment of HBE cells."
20215869
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"Three observations suggest that Cif may inhibit USP10 activity by stabilizing the interaction between USP10 and G3BP1, which inhibits USP10 DUB activity, and also reduces the interaction between USP10 and CFTR."
21455491
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"As shown in xref , USP10 interacts with CFTR in the early endosomes isolated from airway epithelial cells, and Cif reduces this interaction by 50±6%."
21455491
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"Thus, studies were conducted to determine if Cif inhibits USP10 activity by stabilizing the interaction between USP10 and G3BP1, and by reducing the interaction between USP10 and CFTR."
21455491
sparser
"In the current study, we show localization and activity of USP10 in the early endosomal compartment of primary bronchial epithelial cells, as well as an interaction between CFTR and USP10 in this compartment."
20215869
sparser
"Thus, USP10 and CFTR interact in the early endosomal compartment of polarized primary human bronchial epithelial cells."
20215869
sparser
"Thus, studies were conducted to determine if Cif inhibits USP10 activity by stabilizing the interaction between USP10 and G3BP1, and by reducing the interaction between USP10 and CFTR."
21455491
reach
"Moreover, USP10 interacted with CFTR in the early endosomes, an important requirement for a DUB to regulate a target protein."
20215869
biogrid
No evidence text available
20215869
reach
"Thus, these observations reveal that Cif stabilizes an interaction between USP10 and G3BP1, and also reduces the interaction between USP10 and CFTR."
21455491
biogrid
No evidence text available
19398555
sparser
"Thus, these observations reveal that Cif stabilizes an interaction between USP10 and G3BP1, and also reduces the interaction between USP10 and CFTR."
21455491
reach
"As shown in XREF_FIG, USP10 interacts with CFTR in the early endosomes isolated from airway epithelial cells, and Cif reduces this interaction by 50 +/-6%."
21455491
reach
"In the current study, we show localization and activity of USP10 in the early endosomal compartment of primary bronchial epithelial cells, as well as an interaction between CFTR and USP10 in this compartment."
20215869
biogrid
No evidence text available
22904170
sparser
"Three observations suggest that Cif may inhibit USP10 activity by stabilizing the interaction between USP10 and G3BP1, which inhibits USP10 DUB activity, and also reduces the interaction between USP10 and CFTR."
21455491