IndraLab

Statements

COPS5 activates DNA Damage. 7 / 7
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"Similarly, the levels of phospho- Chk2, a key molecule in the transduction of DNA damage signals [XREF_BIBR], increased in NPC cells after DNA damage exposure regardless of whether the cells were treated with Jab1 and CSN5 siRNA (although the phospho-Chk2 levels were higher in Jab1 and CSN5 deficient cells)."
22867945
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"91 In ESCs, overexpression MTCH2 rescues the COPS5 knockout induced growth defect, reduced glycolysis, enhanced OXPHOS, elevated reactive oxygen species (ROS) and subsequent DNA damage accumulation,90 suggesting that MTCH2 facilitates ESC maintaining genome integrity and self-renewal capacity."
38882047
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"These results indicated that Jab1 and CSN5 deficiency enhances DNA damage and decreases DNA repair in NPC cells after exposure to DNA damaging stimuli."
22867945
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"By building on these findings, we found that Jab1 and CSN5 sensitized mouse embryonic fibroblasts to gamma radiation induced apoptosis and increased spontaneous DNA damage that could be attributed to reduced levels of the DNA repair protein Rad51 and increased levels of p53 [XREF_BIBR]."
20955608
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"These results indicate that Jab1 deficiency enhances DNA damage and decreases DNA repair after exposure to DNA damage stimuli."
22797071
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"Jab1 shRNA treated cells had higher levels of cleaved caspase-3 and gamma-H2AX after cisplatin, IR and UV exposure (XREF_FIG, Top), supporting our hypothesis that Jab1 depletion enhances genotoxic stress induced apoptosis and DNA damage."
22797071
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"On one hand, Cops5 suppresses the autophagic degradation of Mtch2 to direct cellular metabolism toward glycolysis and minimize reactive oxygen species (ROS) production, thereby reducing endogenous DNA damage."
31964807