IndraLab

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OTUB1 activates cell population proliferation. 26 / 27
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"Moreover , knockdown of OTUB1 suppressed cell migration ( Fig. 2d ) and invasion ( Fig. 2e ) of RCC , suggesting that OTUB1 might contribute to cell proliferation and malignant phenotypes of RCC ."
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"We finally determined that OTUB1 promotes the proliferation and progression of PCa via deubiquitinating and stabling Cyclin E1."
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"In this study, OTUB1 enhanced the proliferation, migration, and invasion of endometriosis cells."
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"In vitro experiments also suggested that OTUB1‐isoform2 promoted ovarian tumour cell proliferation and invasion."
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"OTUB1 promotes cell proliferation and epirubicin resistance through targeting FOXM1."
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"Overexpression OTUB1 obviously promoted the proliferation and migration of PC3 and C4-2 cells via mediating the deubiquitinated Cyclin E1, while OTUB1 knockout has the opposite effect."
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"The results showed that OTUB1 overexpression promoted the proliferation and growth of 11Z and HESC cells (Figures 4A and 4B)."
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"As discussed above, activation of mTOR via IL-2R signaling allows selective mRNA translation, including the epistatic regulator of GRAIL, Otub1, whose expression results in the degradation of GRAIL and allows T cell proliferation."
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"Hence, the overexpression of OTUB1 contributes to the aberrant proliferation and epirubicin resistance of MCF7 cells and correlates with poor survival and chemotherapy resistance of breast cancer cohort."
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"However , in our study , we discovered that high level of OTUB1 promoted cell proliferation , while low expression of OTUB1 had the opposite effect ."
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"Thus, the loss of function of OTU1 likely reduces cell proliferation but promotes cell expansion."
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"Taken together, these results suggest that the expression of OTUB1‐isoform2 is independent of its isoform OTUB1 in ovarian cancer.3.3 OTUB1-isoform2 promoted ovarian cancer cell proliferation."
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"In this sense, OTUB1 may promote colon cancer proliferation, metastasis and recurrence through TGFbeta signal pathway."
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"In line with the clinical results of OTUB1 in RCC , in vitro functional assays revealed that knockdown of OTUB1 inhibited cell proliferation , migration and invasion of RCC cells ."
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"A growing body of literature demonstrates that the DUB Otubain 1 (OTUB1) regulates many cancer associated signaling pathways including MAPK, ERa, epithelial-mesenchymal transition (EMT), RHOa, mTORC1, FOXM1 and P53 to promote tumor cell survival, proliferation, invasiveness and therapeutic resistance."
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"Knockdown of OTUB1 suppressed cell proliferation , migration and invasion of RCC ."
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"Activation of mTOR allows selective mRNA translation, including the epistatic regulator of GRAIL, Otubain-1 (Otub1), whose expression results in the degradation of GRAIL and allows T cell proliferation."
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"18 In here, we not only show that the potent oncogene FOXM1 is a target of OTUB1 but also present evidence to demonstrate that the oncogenic and genotoxic functions of OTUB1 depend on the expression of a functional FOXM1, suggesting that OTUB1 promotes cell proliferation and epirubicin resistance predominantly through targeting FOXM1."
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"The result showed that overexpression of OTUB1 significantly enhanced MCF-7 cell proliferation, whereas OTUB1 depletion decreased the rates of proliferation of MCF-7 cells (XREF_SUPPLEMENTARY)."
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"Furthermore, addition of IL-2 was able to activate the mTOR pathway, inducing Otubain-1 expression, which mediated GRAIL degradation and improved T cell proliferation."
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"Conclusions : Our findings reveal the critical role of OTUB1 in PCa, and OTUB1 promotes the proliferation and progression of PCa via deubiquitinating and stabilizing Cyclin E1."
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"Overexpression of OTUB1, but not the OTUB1 (C91S) mutant, significantly enhanced the cell proliferation as well as the viability of WT MEFs in response to epirubicin (XREF_FIG)."
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"Through in vitro and in vivo experiments, knockdown of OTUB1 suppressed PTC cells growth whereas OTUB1 overexpression enhanced the proliferation ability of PTC cells."
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"OTUB1 Promotes Progression and Proliferation of Prostate Cancer via Deubiquitinating and Stabling Cyclin E1."
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"Through in vitro experiments, the knockdown of OTUB1 inhibited the proliferation, migration and tube formation of human hemangioma endothelial cells, while the overexpression of OTUB1 promoted the proliferation, migration and angiogenic abilities of human hemangioma endothelial cells."
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"Taken together, OTUB1 promotes the proliferation and migration of endometriosis cells."
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