
IndraLab
Statements
OTUB1 activates cell population proliferation. 64 / 65
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60
reach
"Besides, ablation of OTUB1 significantly increased the proliferation and viability of 4T1 cells, while overexpression of CCN6 in OTUB1 cells reversed the effect (Figure 5D–F and Figure S10B), suggesting that OTUB1 inhibits breast cancer proliferation and viability by elevating CCN6 levels."
reach
"A growing body of literature demonstrates that the DUB Otubain 1 (OTUB1) regulates many cancer associated signaling pathways including MAPK, ERa, epithelial-mesenchymal transition (EMT), RHOa, mTORC1, FOXM1 and P53 to promote tumor cell survival, proliferation, invasiveness and therapeutic resistance."
reach
"18 In here, we not only show that the potent oncogene FOXM1 is a target of OTUB1 but also present evidence to demonstrate that the oncogenic and genotoxic functions of OTUB1 depend on the expression of a functional FOXM1, suggesting that OTUB1 promotes cell proliferation and epirubicin resistance predominantly through targeting FOXM1."
reach
"Through in vitro experiments, the knockdown of OTUB1 inhibited the proliferation, migration and tube formation of human hemangioma endothelial cells, while the overexpression of OTUB1 promoted the proliferation, migration and angiogenic abilities of human hemangioma endothelial cells."