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"Besides, ablation of OTUB1 significantly increased the proliferation and viability of 4T1 cells, while overexpression of CCN6 in OTUB1 cells reversed the effect (Figure 5D–F and Figure S10B), suggesting that OTUB1 inhibits breast cancer proliferation and viability by elevating CCN6 levels."

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"A growing body of literature demonstrates that the DUB Otubain 1 (OTUB1) regulates many cancer associated signaling pathways including MAPK, ERa, epithelial-mesenchymal transition (EMT), RHOa, mTORC1, FOXM1 and P53 to promote tumor cell survival, proliferation, invasiveness and therapeutic resistance."

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"In addition, Liao et al. (2020) also found OTUB1 promotes the progression and proliferation of prostate cancer cells."

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"These results were also consistent with those of the SLC7A11 knockdown, validating that the knockdown of OTUB1 promoted ferroptosis and inhibited the proliferation in PASMCs via SLC7A11."

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"In prostate cancer, OTUB1 was reported to promote cell proliferation and invasion (38, 39)."

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"Knockdown of OTUB1 markedly inhibited the proliferation and migration of LN229 and U87MG cells while increasing apoptosis."

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"OTUB1 overexpression significantly accelerated HCC cell proliferation and invasion as RACK1 did; OTUB1 overexpression lost stimulation upon the RACK1-deficient HCC cells."

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"OTUB1 Promotes Progression and Proliferation of Prostate Cancer via Deubiquitinating and Stabling Cyclin E1."

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"The results showed that OTUB1 overexpression promoted the proliferation and growth of 11Z and HESC cells (Figures 4A and 4B)."

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"Furthermore, addition of IL-2 was able to activate the mTOR pathway, inducing Otubain-1 expression, which mediated GRAIL degradation and improved T cell proliferation."

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"OTUB1 supported gastric cancer proliferation and metastasis via enhancing Hippo/YAP axis activity."

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"18 In here, we not only show that the potent oncogene FOXM1 is a target of OTUB1 but also present evidence to demonstrate that the oncogenic and genotoxic functions of OTUB1 depend on the expression of a functional FOXM1, suggesting that OTUB1 promotes cell proliferation and epirubicin resistance predominantly through targeting FOXM1."

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"Activation of mTOR allows selective mRNA translation, including the epistatic regulator of GRAIL, Otubain-1 (Otub1), whose expression results in the degradation of GRAIL and allows T cell proliferation."

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"However , in our study , we discovered that high level of OTUB1 promoted cell proliferation , while low expression of OTUB1 had the opposite effect ."

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"In supplementary materials Fig. S2a, RACK1 silencing reversed the OTUB1-induced cell proliferation in SCC-25 cells and CAL-27 cells."

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"Currently, the only deubiquitinating enzyme of HSF1 reported is OTUB1, which promotes the proliferation and invasion of endometrial cells by promoting the protein stability of HSF1 through its deubiquitination [41], and they are colocalized in both the cytoplasm and nucleus."

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"OTUB1 was reported to promote prostate cancer cell proliferation and invasion (38, 39), which we further confirmed in this study with cell counting, CCK-8, and colony-formation assay in three different cell lines (Figs."

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"Taken together, OTUB1 promotes the proliferation and migration of endometriosis cells."

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"Thus, the loss of function of OTU1 likely reduces cell proliferation but promotes cell expansion."

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"The CCK8 assay showed that OTUB1 depletion inhibited cancer cell proliferation in AGS and MKN28 cells (Fig. 3A, B)."

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"The results showed that overexpression of OTUB1 significantly promoted cell proliferation, whereas knockdown of it apparently inhibited the proliferation, revealed by CCK-8 assay (Fig. 4A, B left panel)."

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"Multiple studies have shown OTUB1 promotes cancer cell proliferation."

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"In this study, OTUB1 enhanced the proliferation, migration, and invasion of endometriosis cells."

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"Taken together, these results suggest that the expression of OTUB1‐isoform2 is independent of its isoform OTUB1 in ovarian cancer.3.3 OTUB1-isoform2 promoted ovarian cancer cell proliferation."

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"Through in vitro experiments, the knockdown of OTUB1 inhibited the proliferation, migration and tube formation of human hemangioma endothelial cells, while the overexpression of OTUB1 promoted the proliferation, migration and angiogenic abilities of human hemangioma endothelial cells."

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"OTUB1 was broadly elevated in HCC tissues and promoted the proliferation and metastasis of HCC in vitro and in vivo."

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"In this sense, OTUB1 may promote colon cancer proliferation, metastasis and recurrence through TGFbeta signal pathway."

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"Silencing OTUB1 promotes apoptosis and cell cycle arrest at G1 phase, inhibiting cell proliferation."

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"Ectopic expression of miR-542-3p which inhibits OTUB1 expression, attenuates proliferation, migration, and invasion while promoting apoptosis in colorectal cancer cells (Yuan et al., 2017)."

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"In vitro experiments also suggested that OTUB1‐isoform2 promoted ovarian tumour cell proliferation and invasion."

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"While OTUB1 promotes the proliferation and migration of breast cancer and ovarian cancer via deubiquitining FOXM1 in the canonical manner, and OTUB1 also facilitates the progression of esophageal canc[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

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"We confirmed that OTUB1 overexpression led to a significant augmentation in both cell proliferation and invasion (Figure S3B,C)."

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"As discussed above, activation of mTOR via IL-2R signaling allows selective mRNA translation, including the epistatic regulator of GRAIL, Otub1, whose expression results in the degradation of GRAIL and allows T cell proliferation."

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"Overexpression OTUB1 obviously promoted the proliferation and migration of PC3 and C4-2 cells via mediating the deubiquitinated Cyclin E1, while OTUB1 knockout has the opposite effect."

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"We finally determined that OTUB1 promotes the proliferation and progression of PCa via deubiquitinating and stabling Cyclin E1."

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"Moreover , knockdown of OTUB1 suppressed cell migration ( Fig. 2d ) and invasion ( Fig. 2e ) of RCC , suggesting that OTUB1 might contribute to cell proliferation and malignant phenotypes of RCC ."

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"Conclusions : Our findings reveal the critical role of OTUB1 in PCa, and OTUB1 promotes the proliferation and progression of PCa via deubiquitinating and stabilizing Cyclin E1."

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"Katzenellenbogen et al. (2023) showed OTUB1 promotes breast cancer cell proliferation through FOXM1."

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"In parallel, Wang et al. showed OTUB1 promotes cancer cell proliferation and migration in ovarian cancer cells."

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"Knockdown of OTUB1 suppressed cell proliferation , migration and invasion of RCC ."

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"OTUB1 knockdown inhibited metastasis and proliferation of GBM cells while promoting apoptosis and cell cycle arrest at the G1 phase in vitro."

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"Notably, YAP1 depletion rescued the cell proliferation and invasion that were induced by OTUB1 overexpression (Figure 4F,G).3."

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"OTUB1 promotes cell proliferation and epirubicin resistance through targeting FOXM1."

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"OTUB1 significantly promoted the proliferation and migration of HCC cells in vitro."

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"Among these DUBs, OTUB1, and USP10 significantly enhanced cell proliferation and invasion (Figure 2A,B, Figure S2A)."

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"Overexpression of OTUB1 promoted GBM cell metastasis, proliferation, G1 to S phase transition, and suppressed apoptosis in vitro."

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"The result showed that overexpression of OTUB1 significantly enhanced MCF-7 cell proliferation, whereas OTUB1 depletion decreased the rates of proliferation of MCF-7 cells (XREF_SUPPLEMENTARY)."

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"A study by Sheryazdanova et al. (2023) identified another mechanism by which OTUB1 promotes lung cancer cell proliferation."

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"In contrast, OTUB1 knockdown decreases oxidative phosphorylation of lung cancer cells and inhibits cell proliferation."

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"Hence, the overexpression of OTUB1 contributes to the aberrant proliferation and epirubicin resistance of MCF7 cells and correlates with poor survival and chemotherapy resistance of breast cancer cohort."

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"These can be characterized by certain marker proteins, likely contributing to OTUB1 overexpression promoting GBM proliferation and invasion."

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"The authors showed OTUB1 inhibits ferroptosis in gastric cancer and promotes cell proliferation as well as migration and invasion."

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"The results of the MTT assay showed that elevated OTUB1 promotes significantly the proliferation ability, while decreased OTUB1 plays the opposite role (Fig. 3D)."

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"Related phenotype experiments also proved that OTUB1 promotes significantly the proliferation and progression of BLCA, which was consistent with previous results (Fig. 3I, J)."

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"Next, we observed that knockdown of OTUB1 inhibits AML cell proliferation and promotes AML cell apoptosis and G0/G1 phase blockade using CCK-8 assay, western blotting, and flow cytometry."

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"Recent research indicates that ETS1, OTUB1 and PTP4A1 could promote OSCC proliferation, invasion, and metastasis (7–9)."

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"Colony-formation assay, EDU assay, and CCK8 assays indicated the suppression of RACK1 partly decreased the HCC cell proliferation caused by OTUB1 overexpression (Fig. 7a, c, e, f, h)."

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"Increasing OTUB1 expression might significantly restrain the extent and outcome of inflammatory damage.These studies have proved that OTUB1 promotes the proliferation and invasion of various cancers v[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

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"The present study demonstrated that OTUB1 induced G1 to S phase transition, suppressed apoptosis, and promoted cell proliferation and invasion in vitro."

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"Overexpression of OTUB1, but not the OTUB1 (C91S) mutant, significantly enhanced the cell proliferation as well as the viability of WT MEFs in response to epirubicin (XREF_FIG)."

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"Through in vitro and in vivo experiments, knockdown of OTUB1 suppressed PTC cells growth whereas OTUB1 overexpression enhanced the proliferation ability of PTC cells."

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"As a result, OTUB1 promotes gastric cancer cell proliferation, migration, and invasion as well as stemness through YAP1."

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"These results demonstrated that OTUB1 might promote OSCC progression by enhancing the ability of cell proliferation, invasion, and migration.We found that OTUB1 affected the function of OSCC cells, an[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

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"In line with the clinical results of OTUB1 in RCC , in vitro functional assays revealed that knockdown of OTUB1 inhibited cell proliferation , migration and invasion of RCC cells ."