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BAP1 activates Ubiquitin. 4 / 4
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"The BAP1 gene produces a 729 AA protein containing several functional domains: a ubiquitin C-terminal hydrolase (UCH) domain, a BRCA1-associated RING domain protein 1 (BARD1) binding domain, an HCF-C1 binding motif (HBM) and a nuclear localization signal ."
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"BAP1 and the BRCA1 and BARD1 complex BRCA1 participates in several multiprotein complexes, and plays roles in : repair of double stranded DNA (dsDNA) breaks by homologous recombination; chromatin remo[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"The deubiquitinase (DUB) and tumor suppressor BAP1 catalyzes ubiquitin removal from histone H2A Lys 119 and coordinates cell proliferation, but how BAP1 partners modulate its function remains poorly understood."
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"As part of the Polycomb repression machinery, BAP1 is activated by the deubiquitinase adaptor domain of ASXL1 mediating gene repression by cleaving ubiquitin (Ub) from histone H2A in nucleosomes."
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