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APEX1 activates APEX1. 24 / 37
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"Designated adenoviral preprotrypsin-leading sequence APE1/Ref-1 (Ad-PPTLS-APE1/Ref-1) was used to overexpress secretory APE1/Ref-1 and assess its role in preventing DOX-induced cardiomyopathy in vitro."
38286792
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"Ubiquitination of APE1 at multiple Lys (Lys 24, 25, 27) residues in the N-terminal domain was shown to modulate the stability or localization of APE1 [XREF_BIBR - XREF_BIBR]."
27655688
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"Collectively, these findings suggest that genotoxic stress upregulates SIRT1 and acetylates APE1, and the increase in SIRT1 expression acts to deacetylate APE1, thereby allowing formation of the APE1 : XRCC1 complex in the BER pathway."
19934257
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"The APX activity was reduced by all seed treatments and the greatest decrease in APX activity were measured with seed treatments of willow extracts ."
| PMC
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"Together, our study demonstrates that increased acetylation levels of APE1 in tumor cells inhibit the limited N-terminal proteolysis of APE1 and thereby maintain the functions of APE1 to promote tumor cells ' sustained proliferation and survival."
26981776
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"Incision activity of APE1 Elevation in APE1 protein level and mostly nuclear subcellular localization raised the question whether this dysregulation in localization alter the DNA repair activity of APE1."
30276167
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"After binding the AP-containing DNA substrate, APE1 is acetylated at multiple N-terminal Lys residues and acetylated APE1 apparently stabilizes the G4 structure in cells while also increasing the residence time of APE1 on the G4 structure to coordinate transcription factors and to act therefore as a gene expression modulator."
36037088
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"Finally, deacetylation of APE1 by SIRT1 promotes the dissociation of APE1 from G4 structures, and, subsequently, 3 ' to 5 ' DNA helicases such as WRN or BLM are recruited to resolve the G4 structures."
32404420
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"It is possible that the dysbiotic microbiota enhance the level of APE1 to provoke redox role or DNA repair activity similar to pathogenic bacteria induced APE1 activity XREF_BIBR."
27471558
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"The regulatory functions modulating the activity of APE1/Ref-1 are complex and controlled through three different mechanisms [29,30]: 1) increase in APE1/Ref-1 expression after transcriptional activation; 2) re-localization of APE1/Ref-1 from the cytoplasm to the nucleus; and 3) modulation of APE1/Ref-1 posttranslational modifications such as acetylation and phosphorylation."
37448293
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"Hsieh et al. [XREF_BIBR] later confirmed that APE1 phosphorylation activated its Ref-1 activity, although in this case protein kinase C (PKC) was responsible for the phosphorylation reaction."
20711647
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"Inhibition of the APEX1 gene or protein by shRNA or an APEX inhibitor , respectively , reduces the proliferation of the MM cells ."
33525741
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"Alternative transcription of Ref1, driven by Znf2, produces a functionally distinct Ref1 isoform."
39475508
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"In agreement with our results, ElSayed et al. [63] documented a significant upregulation of the APX gene in Phaseolus vulgaris seedlings exposed to 200 mM of NaCl for 3 h and 14 days.The increased APX gene expression, supporting the aforementioned increase in APX activity, accelerates the ASA-GSH cycle in regenerating ascorbates at the expense of GSH oxidation."
35736763
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"Methylation of APE1 enhanced its interaction with the mitochondrial protein, Tom20, and stimulated the mitochondrial translocation of APE1 in cells exposed to oxidative agents."
32679368
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"Ape1/Ref-1 binds to the DNA scaffolding protein PCNA ( Dianova et al., 2001 ) and also interacts in vitro and in vivo with p53, although it is unclear whether the Ape1/Ref-1–p53 interaction stimulates[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
17560642
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"These data together suggest that acetylation of APE1 induces a conformational change in APE1."
27994014
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"High levels of APE1 and Ref -1 in patient samples as well as patient derived cell lines support the investigation of APE1 and Ref -1 as a novel target in bladder cancer."
31413178
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"LtgA enhances the activity of Ape1 and an impaired LtgA results in a dysfunctional Ape1 , and appears to poison the cell wall machinery with devastating effects toward the survival of Neisseria in the host ."
32022687
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"Especially, the development of adipose tissue-specific APE1/Ref-1 knockout animals will contribute to identifying the biological role of APE1/Ref-1 in adipose tissue.In conclusion, our study demonstrated that endogenous APE1/Ref-1 is downregulated during adipocyte differentiation, whereas overexpression of APE1/Ref-1 inhibits adipocyte differentiation; in contrast, silencing APE1/Ref-1 and redox inhibition using E3330 promotes adipocyte differentiation through the modulation of expression of adipogenic transcriptional factors."
36834665
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"APE1 acetylation induces a conformational change in APE1 which enhances the AP endonuclease activity of APE1 and its interaction with downstream BER proteins."
27994014
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"This may also facilitate the recruitment of histone acetyltransferase p300 to acetylate APE1 and acetylation in turn enhances the endonuclease activity of APE1 and promotes faster repair."
31575655
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"Lu and coworkers [42] showed that expression of APX in chloroplasts of sweet potato enhanced drought resistance and capacity for recovery from drought stress.At T2, the majority of the cultivars experienced an increase in APX activity."
35890438
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"The redox status of a cysteine residue in the carboxy-terminal TAD (TAD-C) has been shown to affect its interaction with CBP and p300 coactivators, and this interaction is positively regulated by redo[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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