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APEX1 activates APEX1. 16 / 29
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"The APX activity was reduced by all seed treatments and the greatest decrease in APX activity were measured with seed treatments of willow extracts ."
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"Together, our study demonstrates that increased acetylation levels of APE1 in tumor cells inhibit the limited N-terminal proteolysis of APE1 and thereby maintain the functions of APE1 to promote tumor cells ' sustained proliferation and survival."
26981776
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"Finally, deacetylation of APE1 by SIRT1 promotes the dissociation of APE1 from G4 structures, and, subsequently, 3 ' to 5 ' DNA helicases such as WRN or BLM are recruited to resolve the G4 structures."
32404420
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"The redox status of a cysteine residue in the carboxy-terminal TAD (TAD-C) has been shown to affect its interaction with CBP and p300 coactivators, and this interaction is positively regulated by redo[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
11248550
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"Ubiquitination of APE1 at multiple Lys (Lys 24, 25, 27) residues in the N-terminal domain was shown to modulate the stability or localization of APE1 [XREF_BIBR - XREF_BIBR]."
27655688
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"Methylation of APE1 enhanced its interaction with the mitochondrial protein, Tom20, and stimulated the mitochondrial translocation of APE1 in cells exposed to oxidative agents."
32679368
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"These data together suggest that acetylation of APE1 induces a conformational change in APE1."
27994014
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"Collectively, these findings suggest that genotoxic stress upregulates SIRT1 and acetylates APE1, and the increase in SIRT1 expression acts to deacetylate APE1, thereby allowing formation of the APE1 : XRCC1 complex in the BER pathway."
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"It is possible that the dysbiotic microbiota enhance the level of APE1 to provoke redox role or DNA repair activity similar to pathogenic bacteria induced APE1 activity XREF_BIBR."
27471558
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"Inhibition of the APEX1 gene or protein by shRNA or an APEX inhibitor , respectively , reduces the proliferation of the MM cells ."
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"Hsieh et al. [XREF_BIBR] later confirmed that APE1 phosphorylation activated its Ref-1 activity, although in this case protein kinase C (PKC) was responsible for the phosphorylation reaction."
20711647
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"High levels of APE1 and Ref -1 in patient samples as well as patient derived cell lines support the investigation of APE1 and Ref -1 as a novel target in bladder cancer."
31413178
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"APE1 acetylation induces a conformational change in APE1 which enhances the AP endonuclease activity of APE1 and its interaction with downstream BER proteins."
27994014
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"Incision activity of APE1 Elevation in APE1 protein level and mostly nuclear subcellular localization raised the question whether this dysregulation in localization alter the DNA repair activity of APE1."
30276167
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"LtgA enhances the activity of Ape1 and an impaired LtgA results in a dysfunctional Ape1 , and appears to poison the cell wall machinery with devastating effects toward the survival of Neisseria in the host ."
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"This may also facilitate the recruitment of histone acetyltransferase p300 to acetylate APE1 and acetylation in turn enhances the endonuclease activity of APE1 and promotes faster repair."
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