IndraLab

Statements

BAP1 activates HCFC1. 4 / 5
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"The BAP1 nuclear deubiquitinase is known to target histones (together with ASXL1 as a Polycomb repressor subunit) and the HCF1 transcriptional co-factor, and we show that BAP1 knockdown in MPM cell lines affects E2F and Polycomb target genes."
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"BAP1 is a deubiquitinase targeting histones and the host cell factor-1 transcriptional co-factor, and plays a role in transcriptional regulation, chromatin modulation, cell cycle regulation, and DNA repair."
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"In a mouse model, absence of one such shared binding partner, BAP1, led to a lack of HCFC1 protein (since BAP1 normally prevents HCFC1 degradation), and these mice exhibited features of myeloproliferative disease."
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"Among these substrates, OGT and HCF-1 levelswere found to decrease upon Bap1 deletion in mice (Dey et al., 2012), supporting a previous report on the stabilization of HCF-1 by BAP1 (Machida et al., 20[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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