IndraLab

Statements

CYLD leads to the acetylation of TUBA. 5 / 5
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"As expected, only the CYLD 1-212 fragment, which mediates the association of CYLD with HDAC6 (XREF_FIG), was able to inhibit HDAC6 activity and subsequent alpha-tubulin deacetylation (XREF_FIG)."
19893491
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"CYLD also induces the acetylation of alpha-tubulin by inhibiting HDAC6 and thus counteracts the depolymerization of microtubules leading to an overall stabilization of the microtubule network [XREF_BIBR]."
21119682
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"CYLD C/S increased the acetylation of alpha-tubulin to the same extent as with full-length, wild-type CYLD (XREF_FIG), indicating that the UCH domain of CYLD is not required for alpha-tubulin acetylation."
19893491
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"As CYLD associates with MTs and colocalizes specifically with acetylated MTs, we hypothesized that CYLD might directly regulate alpha-tubulin acetylation to control its own localization."
19893491
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"CYLD induces acetylation of alpha-tubulin and stabilization of MTs."
19893491