IndraLab

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HCN1 inhibits exocytosis. 7 / 7
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"Altogether, these findings strongly suggest that HCN1 channels present in a subset of mature EC synaptic boutons reduce the rate of synaptic vesicle exocytosis during evoked release."
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"Thus, these findings further strongly re-inforce the notion that native HCN1 subunits located in a subset of synaptic terminals within EC layer III significantly reduce the rate of exocytosis during synchronous release."
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"In this study, using HCN1 null mice and their respective wildtype littermates together with FM1-43 imaging, electrophysiology, two photon microscopy and pharmacology, we show that endogenous HCN1 channels present in a subset of adult EC synaptic terminals substantially restrict the rate of exocytosis and thereby, spontaneous non action potential- and action potential- dependent as well as synchronous (evoked) synaptic transmission (XREF_FIG, XREF_FIG, XREF_FIG)."
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"This coupled with electrophysiology and pharmacology showed that HCN1 channels restrict the rate of exocytosis from a subset of cortical synaptic terminals within the EC and in this way, constrain non action potential dependent and action potential dependent spontaneous release as well as synchronous, evoked release."
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"HCN1 channels reduce the rate of exocytosis from a subset of cortical synaptic terminals."
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"Moreover, because there were significant changes in puncta fluorescence between HCN1 null slices and wildtype slices during the 1.5 Hz stimulation, this suggests that pre-synaptic HCN1 channels restrict exocytosis during synchronous (evoked) release too."
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"Hence, these findings further support the notion that HCN1 channels restrict exocytosis during evoked release."
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