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HCN1 inhibits exocytosis. 7 / 7
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7
reach
"This coupled with electrophysiology and pharmacology showed that HCN1 channels restrict the rate of exocytosis from a subset of cortical synaptic terminals within the EC and in this way, constrain non action potential dependent and action potential dependent spontaneous release as well as synchronous, evoked release."
reach
"In this study, using HCN1 null mice and their respective wildtype littermates together with FM1-43 imaging, electrophysiology, two photon microscopy and pharmacology, we show that endogenous HCN1 channels present in a subset of adult EC synaptic terminals substantially restrict the rate of exocytosis and thereby, spontaneous non action potential- and action potential- dependent as well as synchronous (evoked) synaptic transmission (XREF_FIG, XREF_FIG, XREF_FIG)."