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UCHL1 activates sub. 2 / 2

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"Thus, upregulated p53 signaling by UCHL1 through its DUB activity was involved in G0/G1 cell cycle arrest and apoptosis in breast cancer cells."

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"The UCH-L1 substrate increases with time, since UCH-L1 overexpression leads to increase DUB activity of its substrate which has the effect of lowering the degradation rate."

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IndraLab

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UCHL1 activates sub. 2 / 2

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