IndraLab

Statements

USP22 activates cisplatin. 14 / 14
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"Wang et al. [10] reported that USP22 induced cisplatin resistance in LUAD by modulating DNA damage repair mediated by γH2AX and apoptosis mediated by Ku70/Bax."
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"To further confirm that USP22 induces cisplatin resistance via Sirt1, we added flow cytometric analysis results."
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"The study reveal the dual mechanism of USP22 involvement in cisplatin resistance : (1) USP22 enhances DNA damage repair and induce cisplatin resistance by promoting the phosphorylation of histone H2AX via deubiquitinating histone H2A."
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"USP22 regulates ALDH activity by transcriptionally regulating ALDH1A3 levels.Enhanced DNA repair processes, increased cell stemness characteristics, and inhibition of apoptotic pathways may be major factors in USP22-induced cisplatin resistance."
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"These results confirm that USP22 is involved in the cisplatin resistance of A549 and CDDP cells and H2AX, gammaH2AX, and Sirt1 may be responsible for USP22 mediated cisplatin resistance."
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"USP22 Induces Cisplatin Resistance in Lung Adenocarcinoma by Regulating gammaH2AX Mediated DNA Damage Repair and Ku70 and Bax Mediated Apoptosis."
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"Overall, downregulation of USP22 is expected to enhance the therapeutic effect of cisplatin in tumors."
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"To verify whether inhibition of USP22 expression could reverse the cisplatin resistance of A549 and CDDP cells, CCK8 assays showed that, after the inhibition of USP22 expression, the 48h IC50 of A549 and CDDP decreased from 0.925 +/- 0.04 muM to 0.337 +/- 0.03 muM."
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"According to that model, USP22 enhances DNA damage repair and cisplatin resistance by deubiquitinating histone H2A, which in turn facilitates the phosphorylation of histone H2AX."
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"To verify whether inhibition of USP22 expression could reverse the cisplatin resistance of A549 and CDDP cells, CCK8 assays showed that, after the inhibition of USP22 expression, the 48h IC50 of A549 and CDDP decreased from 0.925 +/- 0.04 muM to 0.337 +/- 0.03 muM."
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"Combining with our previous results, we concluded that both USP22 and Sirt1 can induce cisplatin resistance, but Sirt1 overexpression ca n't phenocopy USP22 mediated cisplatin resistance."
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"We previously demonstrated that USP22 contributes cisplatin chemotherapy resistance, and knockdown of USP22 sensitized lung cancer cells to cisplatin [28, 38], while a previous study found that USP7-silenced A549 cells had enhanced sensitivity to paclitaxel and docetaxel, but there was no significant change in sensitivity toward carboplatin and cisplatin [53]."
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"Moreover, the resistance degree of USP22 mediated cisplatin resistance was higher than Sirt1 mediated cisplatin resistance."
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"Unlike 5-FU resistance mechanisms, USP22 increases tumor resistance to cisplatin by enhancing DNA repair capacity."
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