IndraLab

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PKA phosphorylates HCN4. 21 / 21
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sparser
"The in vitro phosphorylation data demonstrated that PKA can directly phosphorylate HCN4 at multiple sites."
20713547
sparser
"First, it was found that HCN4 can be phosphorylated by cAMP-dependent protein kinase A (PKA) at the distal C-terminus, in addition to the well-studied cAMP binding to a conserved cyclic nucleotide binding domain in the proximal C-terminus ( xref )."
30538641
reach
"PKA could directly phosphorylate HCN4 and, thus, regulate ion current changes [XREF_BIBR]."
27069490
reach
"To determine whether PKA can directly phosphorylate HCN4, we next performed in vitro phosphorylation assays."
20713547
sparser
"In vitro phosphorylation assays and mass spectrometry revealed that PKA can directly phosphorylate at least 13 sites on HCN4, including at least three residues in the N terminus and at least 10 in the C terminus."
20713547
sparser
"cAMP potentiates voltage-dependent activation of I f either by binding directly to HCN4 channels ( xref ; xref ) or by protein kinase A (PKA)–mediated phosphorylation of HCN4 channels ( xref )."
28057842
sparser
"We identified at least 13 residues in the intracellular N and C termini of HCN4 that can be phosphorylated by PKA in vitro."
20713547
reach
"Densitometric analysis was used to quantitate the PKA dependent phosphorylation of HCN4."
20713547
reach
"This correspondence makes these positions particularly strong candidates for further analysis of PKA phosphorylation of HCN4 channels in vivo."
20713547
sparser
"PKA could directly phosphorylate HCN4 and, thus, regulate ion current changes [ xref ]."
27069490
sparser
"At least 13 residues were identified in the intracellular N and C termini of HCN4 that can be phosphorylated by PKA in vitro ."
27069490
reach
"However, we have recently shown that Protein Kinase A (PKA) activity is required for sympathetic regulation of I (f) and that PKA can directly phosphorylate HCN4."
21150293
sparser
"However, we have recently shown that Protein Kinase A (PKA) activity is required for sympathetic regulation of I(f) and that PKA can directly phosphorylate HCN4."
21150293
reach
"The in vitro phosphorylation data demonstrated that PKA can directly phosphorylate HCN4 at multiple sites."
20713547
reach
"cAMP potentiates voltage dependent activation of I f either by binding directly to HCN4 channels or by protein kinase A (PKA)-mediated phosphorylation of HCN4 channels."
28057842
sparser
"This correspondence makes these positions particularly strong candidates for further analysis of PKA phosphorylation of HCN4 channels in vivo."
20713547
sparser
"Densitometric analysis was used to quantitate the PKA-dependent phosphorylation of HCN4."
20713547
sparser
"PKA phosphorylates multiple sites on HCN4."
20713547
reach
"From these studies, it seems clear that PKA can phosphorylate HCN4 and that PKA phosphorylation alters the voltage dependence of HCN4 activation."
20713549
sparser
"From these studies, it seems clear that PKA can phosphorylate HCN4 and that PKA phosphorylation alters the voltage dependence of HCN4 activation."
20713549
sparser
"To determine whether PKA can directly phosphorylate HCN4, we next performed in vitro phosphorylation assays."
20713547