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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

BRAF-D594G activates ERK. 2 / 2

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"By contrast, kinase-dead BRAF D594G and low activity BRAF G466E and D287H marginally activated ERK signaling and did n't inhibit RAS function."

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"The BRAF mutants G466V, D594A, D594G, D594E, D594N, D594V and G596C did not induce MEK or ERK activation compared to wt-BRAF."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...