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USP10 deubiquitinates TP53. 73 / 75
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"We also developed a UbV targeting USP10, a second DUB that deubiquitinates p53, and showed that the UbV promoted export of p53 from the nucleus to the cytoplasm."
30851297
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"This is accomplished by several deubiquitination enzymes including USP7 that deubiquitinates Mdm2 to stabilize p53 [XREF_BIBR] as well as USP10 and USP42 that can directly deubiquitinate p53 upon DNA damage [XREF_BIBR, XREF_BIBR]."
28208785
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"USP10 deubiquitinates p53 and reverses Mdm2 mediated p53 nuclear export and degradation, suggesting that USP10 may act as a tumor suppressor by activating p53."
20531303
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"Some well-established examples include histone deubiquitination by Ubp8 (24), p53 deubiquitination by both Usp7 and Usp10 (25, 26), free K48-linked ubiquitin-chain disassembly by Ubp14 (27), and removal of K63-linked ubiquitin chain from TRAF6 by A20 (28, 29)."
39798877
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"Additionally, a cytoplasmic DUB, ubiquitin-specific peptidase 10 (USP10) deubiquitinates p53 and prevents Mdm2-induced p53 nuclear export and degradation."
36613989
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"It is reported that USP10 deubiquitinates p53, reversing Mdm2 induced p53 nuclear export and degradation [XREF_BIBR]."
29142505
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"Interestingly, Beclin 1 can also modulate p53 protein stability by regulating the activities of USP10/USP13, which can deubiquitinate p53 ."
36528652
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"Besides, absence of estrogen causes cellular senescence through downregulation of USP10, which deubiquitinates p53 and stimulates bone formation, suggesting USP10 as a positive regulator of bone development [154]."
40170748
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"Here we report that USP10, a cytoplasmic ubiquitin specific protease, deubiquitinates p53, reversing Mdm2 induced p53 nuclear export and degradation."
20096447
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"USP10 mediates the deubiquitination of p53, and as Beclin-1 regulates the deubiquitination activity of USP10 and USP13, Beclin-1 can control the levels of p53."
26530936
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"However, a recent study has shown that the VPS34 and Beclin -1 complex can act as a regulator of p53 due to its regulatory effect on the ubiquitin specific protease, USP10, which mediates p53 deubiquitination."
33262756
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"Since USP10 mediates the deubiquitination of p53, regulation of the deubiquitinase activity of USP10 and USP13 by Beclin 1 may provide a mechanism by which it can control the p53 protein levels."
24956373
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"Since USP10 mediates the de-ubiquitination of p53, regulating de-ubiquitination activity of USP10 and USP13 by Beclin1 provides a mechanism for Beclin1 to control the levels of p53."
28575052
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"USP10 also promotes the deubiquitination of p53, although the precise interaction domain within p53 has not yet been mapped."
30067985
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"USP10 is a mainly cytoplasmic DUB which deubiquitinates p53 and reverses Mdm2-induced p53 nuclear export and degradation ( Fig. 6 ) ( Yuan et al., 2010 )."
25444757
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"Furthermore, Beclin1 can alter p53 expression by regulating deubiquitination of p53 by USP10 43."
28808340
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"Resveratrol, on the other hand, directly binds to G3BP1 and disrupts the G3BP1 and USP10 interaction, resulting in enhanced USP10 regulated deubiquitination of p53."
24998844
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"Because USP10 is a p53 deubiquitinating enzyme, p53 ubiquitination was decreased by transfection of USP10 (compare lanes 3 and 4), whereas deubiquitination of p53 by USP10 was inhibited by co-transfection of USP10 and G3BP1 (compare lanes 4 and 5)."
24998844
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"G3BP1 also inhibited USP10 mediated deubiquitination of endogenous p53 in HCT116 cells (XREF_FIG)."
24998844
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"This process is very important during DNA-damage response, in which USP10 translocates to the nucleus and deubiquitinates p53, stabilizing it and thus regulating its response to DNA damage [113,114,115]."
32075244
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"A third DUB, USP10, also deubiquitinates p53 counteracting its ubiquitination and degradation by Mdm2 [178] ."
22033037
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"USP10 deubiquitinates p53."
20096447
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"We conjectured that G3BP1 disrupts the interaction of USP10 with p53 by binding to USP10, and consequently suppresses USP10 mediated deubiquitination of p53."
24998844
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"Resveratrol enhances USP10 mediated deubiquitination of p53 by disrupting the G3BP1 and USP10 interaction."
24998844
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"Since USP10 also deubiquitinates wild-type p53, Spautin-1 promotes degradation of wild-type p53."
26732534
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"It is likely that USP10 functions to deubiquitinate p53 to counteract the action of E3 ubiquitin ligases such as Mdm2."
20096447
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"USP10 can also directly deubiquitinate and stabilize p53, reversing nuclear export and degradation of p53 induced by MDM2."
30319415
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"These results strongly indicate that resveratrol enhances USP10 mediated deubiquitination of p53 by disrupting the G3BP1 and USP10 interaction."
24998844
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"Overall, our study demonstrates that resveratrol directly targets G3BP1, which in turn prevents the G3BP1 and USP10 interaction and consequently increases USP10 regulated deubiquitination of p53 (XREF_FIG)."
24998844
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"Mechanistically, USP10 can reverse the activity of Mdm2 through deubiquitinating p53 in the cytoplasm, causing the return of p53 from the cytoplasm to the nucleus and affecting the nuclear output of the p53 protein."
35627217
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"For example, USP10 and USP29 can directly deubiquitinate p53 [30,31], while USP5 regulates p53 levels and alters cell growth that is associated with p21 induction [32]."
35884607
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"Mechanically, USP10 deubiquitinates p53, contributes to p53 stability, and thereby retains its activity."
38847328
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"Therefore, deubiquitination of p53 by USP7 or USP10 are indispensible for p53 transcription and transcription-independent cell death [20,22] ."
20226183
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"USP10 deubiquitinates and stabilizes the tumor suppressor p53, and SIRT6."
27974222
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"Moreover, they also found that p53, which can be deubiquitinated by USP10, negatively regulates the expression of miR-138 through binding to the miRNA’s promoter region [31]."
35627217
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"Resveratrol (RSVL) directly binds to G3BP1 and prevents the interaction of G3BP1/USP10, which enhances the USP10-mediated de-ubiquitination of p53, thereby increasing p53 expression (135)."
34526993
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"Since p53 is an important tumor suppressor that regulates cell proliferation and USP10 potentiates p53 function by deubiquitinating p53, it is possible that USP10 also acts as a tumor suppressor."
20096447
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"USP10 deubiquitinates both wild-type p53 and mutp53."
32722796
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"USP10 deubiquitinates both wild-type p53 and mutp53."
32722796
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"It will be intriguing to assess when and how USP10 could deubiquitinate different proteins in vitro and in vivo.In contrast to the tumor-suppressor role of USP10 in p53-WT cancer cells, USP10 exerts an oncogenic function in p53-mutant cancer cells."
35627217
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"It was demonstrated that in unstressed cells, USP10 is localized to the cytoplasm and inhibits p53 ubiquitination."
22033037
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"USP10, a DUB present in the cytosol, directly deubiquitinates p53."
28216291
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"In the case of DNA damage, the phosphorylation of USP10 at Thr42 and Ser337 mediated by ATM is essential for its translocation to the nucleus, where USP10 induces the deubiquitination of p53 and makes p53 work as a tumor suppressor."
32140262
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"Interestingly, both USP7 and USP10 are involved in regulation of the tumor suppressor protein p53 where USP7 and USP10 cooperatively deubiquitinate p53."
33095475
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"In the nucleus, USP10 then deubiquitinates p53 leading to its activation and subsequent growth suppression."
22033037
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"For example, USP7 and USP10 bind to and deubiquitylate their substrate p53 to mediate its role for suppression of cell propagation upon cellular stresses by counteracting its degradation ."
31745110
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"In animal, USP7, USP10 and USP42 bind to and deubiquitylate the substrate p53 to counteract its degradation ."
31745110
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"USP10 deubiquitinates p53 to reverse the Mdm2-induced p53 nuclear export and degradation (Yuan et al., 2010)."
31282934
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"USP4, for example, interacts directly with end resection factors CtIP and MRN [172], USP21 deubiquitinates and stabilizes BRCA2 to promote RAD51 binding and successful HR [173], and USP10 deubiquitinates and stabilizes p53 to promote its nuclear localization and apoptosis in response to DSBs [174]."
32708614
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"The deubiquitinase activity of HAUSP and USP10 exist in different compartments : HAUSP deubiquitinates and stabilizes p53 primarily in the nucleus [XREF_BIBR], whereas USP10 largely deubiquitinates cytoplasmic p53 during homeostasis, although it retains deubiquitinase activity upon translocation to the nucleus following DNA damage [XREF_BIBR]."
20932800
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"Another DUB, USP10 deubiquitinates p53, but not MDM2 or MDMX."
29479529
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"These results suggest that USP10 negatively regulates p53 ubiquitination in cells."
20096447
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"Under stress condition, ATM phosphorylates USP10, which then deubiquitinates and targets cytoplasmic p53 back to the nucleus."
29479529
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"Since USP10 mediates the deubiquitination of p53, regulating deubiquitination activity of USP10 and USP13 by Beclin1 provides a mechanism for Beclin1 to control the levels of p53."
21962518
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"USP10 interacts with p53 and deubiquitinates p53 to stabilize it."
39748950
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"As shown in XREF_FIG, purified WT USP10, but not catalytically inactive USP10 effectively deubiquitinated p53 in vitro."
20096447
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"These results demonstrate that USP10 deubiquitinates p53 both in vitro and in vivo."
20096447
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"However, it is unclear whether USP10 antagonizes ubiquitination of mutp53 by other ubiquitin ligases, USP10 alters subcellular localization of mutp53, and USP10 plays a role in deubiquitination of different TP53 mutants."
30577483
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"BECN1 also regulates the stability of the proteins USP10 and USP13, which might explain the novel observation 200 that BECN1 regulates p53 levels, as USP10 mediates p53 deubiquitylation."
22935804
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"A large fraction of USP10 is localized to the cytoplasm and indeed a recent publication showed that USP10 deubiquitylates p53 and regulates its stability."
21245042
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"Since USP10 mediates the deubiquitination of p53, regulating deubiquitination activity of USP10 and USP13 by Beclin1 provides a mechanism for Beclin1 to control the levels of p53 [XREF_BIBR]."
22829831
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"Once in the cytoplasm, p53 can be deubiquitinated by the deubiquitinase USP10, resulting in its translocation back to the nucleus (Yuan et al., 2010) [pathway (3) in Figure 2]."
22188262
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"USP10 normally de-ubiquitinates p53 in response to DNA damage, opposing the action of Mdm2 and allowing p53 protein accumulation."
23606570
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"USP10, a cytoplasmic DUB, directly deubiquitinates TP53 and regulates the subcellular localization and stability of TP53 by antagonizing the action of MDM2 [43]."
36551253
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"USP10 can deubiquitinate cytoplasmic p53 and inhibit MDM2-mediated p53 nuclear export and degradation."
32571254
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"USP10, a cytoplasmic ubiquitin-specific protease, deubiquitinates p53, reversing Mdm2-induced p53 nuclear export and degradation [44]."
39875925
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"In contrast to USP7 and USP2a, USP10 specifically deubiquitinate p53 because knockdown of USP10 in HCT116 p53-/- cells does not cause Mdm2 reduction [XREF_BIBR]."
28031783
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"In contrast to HAUSP and USP2a, USP10 appears to specifically deubiquitinate p53 because knockdown of USP10 in HCT116/p53−/− cells does not cause reduction in Mdm2."
22673503
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"LINC00460 also further promotes pancreatic cancer development by sequestering USP10, a cytoplasmic ubiquitin-specific protease that deubiquitinates p53 and enhances its stability."
37786443
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"In response to DNA damage, USP10 translocates to the nucleus and deubiquitinates p53, and further prevents p53 from nuclear export and degradation [7] ."
28807825
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"Jian Yuan discovered that USP10 potentiated p53 function by deubiquitinating p53 and acted as a tumor suppressor in renal cell carcinoma [ 24 ]."
37757903
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"USP10 deubiquitinates p53 and reverses MDM2 mediated nuclear transport and degradation of p53."
25606592
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"We confirmed that wild-type USP10 but not USP10 C424A deubiquitinates the p53 protein (XREF_SUPPLEMENTARY C)."
30469013