IndraLab

Statements

RHEB-Q64L activates MTOR. 3 / 3
| 3
reach
"To further determine whetherENDOG mediated autophagy promotion is mTOR dependent, we used a constitutively active form of RHEB (RHEB Q64L) to continuously activate mTOR 19."
33473107
reach
"As a result, compared to the empty vector controls, RHEB Q64L partially restored mTOR activity, as shown by the increased phosphorylation of ULK1 and 4EBP1."
33473107
reach
"Given the fact that ENDOG induced autophagy has only been partially restored in the presenceof RHEB Q64L, which continuously activates mTOR, we reasoned that an additional pathway might exist in ENDOG promoted autophagy."
33473107