IndraLab

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Curcumin inhibits MYD88. 10 / 10
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"Therefore, curcumin can inhibit LPS-induced activation of both MyD88- and TRIF-dependent pathways of TLR4, and results in the inhibition of both NF-kB and interferon regulatory factor 3 (IRF3) (36)."
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"Plant‐derived compounds that have shown effects on these pathways include curcumin isolated from Curcuma longa, which inhibits TLR2, MyD88 and NF‐κB p65 expression in the CIA rat model, and NF‐κB activation by interfering with the phosphorylation and degradation of IκB‐α [60, 61, 62, 63]."
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"To investigate the effect of curcumin on IAV-induced activation of TLRs signaling pathway, we had constructed a series of promoter luciferase reporter plasmids, and based on the analysis of these prom[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Li et al. found that curcumin supplementation significantly blocks the activation of TLR4/MyD88, followed by inhibiting the activation of NF-κB and its downstream genes’ expression, including iNOS, IL-6, IL-1β, and TNF-α genes [34]."
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"Additionally, MYD88, NLRC4 and TXNIP were downregulated by curcumin."
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"It has been shown that curcumin inhibits not only the IkappaB kinase (IKK) beta in the MyD88 signaling pathway but also the MyD88 independent pathway upstream of Toll and IL-1R domain containing adaptor inducing IFN-beta (TRIF)."
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"Curcumin also markedly inhibited the upregulation of toll like receptor 4 (TLR4), myeloid differentiation factor 88 (MyD88), phosphorylation level of IkappaB-alpha, and activation of NF-kappaB in PMA induced macrophages."
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"Curcumin was demonstrated to inhibit TLR4/MyD88, NF- κB, and P2X7R in phorbol 12-myristate 13- acetate-induced macrophages, which resulted in decreased activation of NLRP3 inflammasomes."
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"These results indicated that curcumin inhibited the TLR4/MyD88 and EGFR signaling pathways in NSCLC cells."
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"Therefore, curcumin inhibits LPS induced activation of both MyD88- and TRIF dependent pathways of TLR4 resulting in the inhibition of both NF-kappaB and IRF3."
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