IndraLab

Statements

Curcumin inhibits MYD88. 5 / 5
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"Curcumin was demonstrated to inhibit TLR4/MyD88, NF- κB, and P2X7R in phorbol 12-myristate 13- acetate-induced macrophages, which resulted in decreased activation of NLRP3 inflammasomes."
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"Therefore, curcumin inhibits LPS induced activation of both MyD88- and TRIF dependent pathways of TLR4 resulting in the inhibition of both NF-kappaB and IRF3."
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"It has been shown that curcumin inhibits not only the IkappaB kinase (IKK) beta in the MyD88 signaling pathway but also the MyD88 independent pathway upstream of Toll and IL-1R domain containing adaptor inducing IFN-beta (TRIF)."
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"Curcumin also markedly inhibited the upregulation of toll like receptor 4 (TLR4), myeloid differentiation factor 88 (MyD88), phosphorylation level of IkappaB-alpha, and activation of NF-kappaB in PMA induced macrophages."
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"Additionally, MYD88, NLRC4 and TXNIP were downregulated by curcumin."
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