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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

COPS6 activates ALDH1A1. 1 / 1

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"Cells with high ALDH1A1 levels have increased expression levels of vimentin , matrix metalloproteinase-2 ( MMP2 ) , MMP7 and MMP9 , which are implicated in epithelial-mesenchymal transition and metastatic capabilities.40 Interestingly , CSN6 is able to promote the expression of ALDH1A1 , a known CSC marker upregulated in cancer spheroids.41 Chromatin immunoprecipitation assays have characterised ALDH1A1 as a direct target of beta-catenin activation ."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...