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COPS6 activates ALDH1A1. 1 / 1

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"Cells with high ALDH1A1 levels have increased expression levels of vimentin , matrix metalloproteinase-2 ( MMP2 ) , MMP7 and MMP9 , which are implicated in epithelial-mesenchymal transition and metastatic capabilities.40 Interestingly , CSN6 is able to promote the expression of ALDH1A1 , a known CSC marker upregulated in cancer spheroids.41 Chromatin immunoprecipitation assays have characterised ALDH1A1 as a direct target of beta-catenin activation ."

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COPS6 activates ALDH1A1. 1 / 1

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