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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

SMO binds IGF1R and IRS1. 2 / 2

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"Furthermore, we show that Smo activity is required for both Shh and IGF-I action and that the IGF-IR and its effector IRS-1 associate with Smo in response to these factors, suggesting that cross talk is already occurring at the receptor level."

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"The results suggest that the molecular mechanism by which Shh and IGF-I integrate their effect on myoblast proliferation and differentiation can already be found at the receptor level via an interaction of Smo with IGF-IR and IRS-1."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...