IndraLab

Statements

CD63 binds CXCR4. 8 / 9
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"Either CD63 or CD63DeltaN formed a complex with CXCR4 at the Golgi apparatus and the late endosomes, while CD63 GD mutants lost the ability to form a complex with CXCR4 exclusively at the Golgi apparatus."
19903263
sparser
"Indeed, Yoshida et al. showed that CD63 had three N-linked glycosylation sites [ xref ], that CD63 interacts with CXCR4 through the N-linked glycans-portion of the CD63 protein and that the complex induces the direction of CXCR4 trafficking to the endosomes/lysosomes, rather than to the plasma membrane."
24884960
reach
"Indeed, Yoshida et al. showed that CD63 had three N linked glycosylation sites [XREF_BIBR], that CD63 interacts with CXCR4 through the N linked glycans-portion of the CD63 protein and that the complex induces the direction of CXCR4 trafficking to the endosomes and lysosomes, rather than to the plasma membrane."
24884960
sparser
"These findings suggest that CD63 interacts with CXCR4 through the N-linked glycans-portion of the CD63 protein and that the complex induces direction of CXCR4 trafficking to the endosomes/lysosomes, rather than to the plasma membrane."
19903263
sparser
"In the present study, it was found that CD63 and its mutant efficiently interact with CXCR4 in live cells and that CD63-induced downregulation and interaction are significantly abrogated by the N-linked glycosylation inhibitor, TM."
19903263
sparser
"For instance, the tetraspanin CD63 interacts with CXCR4 on activated B cells and downregulates this receptor ( xref )."
30787933
sparser
"Either CD63 or CD63DeltaN formed a complex with CXCR4 at the Golgi apparatus and the late endosomes, while CD63 GD mutants lost the ability to form a complex with CXCR4 exclusively at the Golgi apparatus."
19903263
reach
"These findings suggest that CD63 interacts with CXCR4 through the N linked glycans-portion of the CD63 protein and that the complex induces direction of CXCR4 trafficking to the endosomes and lysosomes, rather than to the plasma membrane."
19903263