
IndraLab
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"Interestingly, RAP80 's access to polyubiquitin chains assembled by RNF8 and RNF168 is regulated by HR promoting factors such as RNF169, which competes with RAP80 for binding sites on polyubiquitin [XREF_BIBR], and the DUBs USP26 and USP37, which degrade polyubiquitin chains to reduce RAP80 accumulation [XREF_BIBR]."