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UCHL1 activates Neoplasm Metastasis. 33 / 37
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"UCH-L1 promotes cancer metastasis in prostate cancer cells through EMT induction."
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"In lung adenocarcinoma, UCHL1 promotes tumor migration, invasion, and metastasis by inhibiting apoptosis and has an important impact on the clinical drug treatment of lung adenocarcinoma."
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"UCHL1 promotes proliferation and metastasis in head and neck squamous cell carcinoma and could be a potential therapeutic target."
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"We demonstrated that UCHL1 re-expression promoted the proliferation, migration and metastasis potential of HCT8 cells both in vitro and in vivo."
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"The de-ubiquitinase UCHL1 promotes gastric cancer metastasis via the Akt and Erk1/2 pathways."
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"UCHL1 has been shown to promote metastasis via the activation of HIF-1 and its overexpression also correlates with poor prognosis in patients with breast and lung cancers [XREF_BIBR]."
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"Together, these data imply that UCH-L1 promotes cancer cell metastasis via beta-catenin-induced EMT (XREF_FIG)."
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"Functionally , UCHL1 promoted metastasis in zebrafish and murine breast cancer xenograft models ."
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"Functionally , we observed that UCHL1 promoted breast cancer migration , extravasation and metastasis both in zebrafish and mice xenograft models ."
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"We used an inhibitor of HIF-1, YC-1, and a plasmid expressing shRNA for HIF-1alpha, shHIF-1alpha, to directly examine the involvement of HIF-1alpha in the formation of pulmonary metastasis enhanced by UCHL1."
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"Functionally, UCHL1 promoted metastasis in zebrafish and murine breast cancer xenograft models."
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"The aberrant expression of UCHL1 was shown to promote distant tumour metastasis via the activation of HIF-1."
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"Altogether , the mice and zebrafish results confirm that UCHL1 promotes breast cancer invasion and metastasis ."
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"UCHL1 expression supports breast and melanoma metastasis to lungs; inhibition of metastasis is achieved by a UCH-L1 inhibitor, LDN57444."
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"To confirm that UCH-L1 promotes pulmonary metastasis in vivo by altering H 2 O 2 levels in the invasive cells, we examined whether UCH-L1-induced ROS generation is blocked by Adv-catalase infection in a MOI dependent manner (10-50 MOI) in vitro."
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"In lung adenocarcinoma , UCHL1 promotes tumor migration , invasion , and metastasis by inhibiting apoptosis and has an important impact on the clinical drug treatment of lung adenocarcinoma ."
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"UCHL1 has been shown to increase metastasis through deubiquitination and stabilization of HIF-1alpha, a central protein in tumor angiogenesis [XREF_BIBR]."
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"The authors investigated whether UCHL1 promotes breast cancer metastasis by overexpressing UCHL1 in mCherry MDA-MB-231 cells, which are UCHL1-low, and knocking down UCHL1 in mCherry MDA-MB-436 cells, which are UCHL1-high, and injecting these cells into zebrafish embryos, showing that UCHL1 overexpression or knockdown provokes a stronger or weaker metastatic phenotype, respectively, compared to untransfected control cells [54]."
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"Considering the recently established functional role of extracellular vesicles (ECV) in cancer progression, we suggest that specific inhibition of C-terminal farnesylation of UCH-L1 may reduce invasion and metastasis of EBV associated LMP1 positive metastatic carcinomas."
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"Ubiquitin carboxyl terminal hydrolase L1 ( UCHL1 ) could abrogate VHL-mediated ubiquitylation of HIF-1alpha and promote metastasis in murine models of pulmonary metastasis [ 79 ] ."
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"UCH-L1 promotes cancer metastasis in prostate cancer cells through EMT induction."
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"The potential role for UCHL1 in promoting breast cancer invasion and metastasis was further supported in a murine breast cancer xenograft model, where UCHL1 overexpressing groups exhibited increased metastasis compared to UCHL1 knockdown groups.To explore the mechanism of action by which UCHL1 promotes breast cancer metastasis, Liu et al. [54] investigated UCHL1 depletion in epithelial–mesenchymal transition (EMT), which has previously been shown to play an important role in breast cancer metastasis [55]."
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"In gastric cancer and lymphoma, the promotion of cancer metastasis caused by UCH-L1 via the PI3 K/Akt signaling pathway has been studied (Hussain et al. 2010; Gu et al. 2015)."
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"We propose that C-terminal farnesylation of UCH-L1 facilitates LMP1 loading in exosomes and might promote tumor invasion and metastasis through modulating the cancer microenvironment."
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"These studies suggest that UCH-L1 promotes cancer cell metastasis."
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"Most of the cancer studies on UCHL1 have revealed that overexpression and promoter methylation of UCHL1 are key reasons for UCHL1 mediated metastasis."
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"UCHL1 is associated with HIF-1 and distant metastasis in cancer patients, suggesting that UCHL1 may promote metastasis through HIF."
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"UCHL1 is a key promoter of cell invasion and metastasis in small cell lung cancer but not necessarily required for cell viability or proliferation [XREF_BIBR, XREF_BIBR]."
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"UCHL1 (Ubiquitin C-terminal hydrolase-L1) has previously been shown to reverse ubiquitylation of HIF-1α and promote metastasis in a HIF-1-dependent manner ."
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"Although our results point to a pivotal role for UCHL1 in stimulating breast cancer extravasation by regulating TGFbeta signaling , we do not preclude that UCHL1 may also promote invasion and metastasis by targeting other signaling proteins ."
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"UCH-L1 has been suggested to promote metastasis in colorectal, lung, and prostate cancer cells [XREF_BIBR, XREF_BIBR, XREF_BIBR]."
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"XREF_BIBR UCHL1 has recently also been shown to promote cancer metastasis in prostate cancer cells."
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"We focused on metastasis as we already determined that UCHL1 induced the expression of metastasis related genes, such as MMP2 and MMP9 (XREF_FIG and XREF_SUPPLEMENTARY)."
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