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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

PDGFR binds IRS1 and PIK3CA. 1 / 1

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"Biochemical analyses have shown that both PIK3CA E545K and PIK3CA H1047R exhibit ~two-fold higher catalytic activity than wild type PI3K. The association of PIK3CA H1047R with PDGFR or IRS-1 phosphopeptides further increases the catalytic activity of the mutant enzyme ( xref )."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...